The purpose of this article is to investigate the nature of spontaneous mental imagery that people experienced after ritualistically ingesting Ayahuasca. The combination of ingestion of Daime and the participation in a ceremony appear to reliably promote the occurrence of spontaneous mental imageries, referred as mirações, which were considered as a process of perception, the moment when...
O. RIOS and M. DOBKIN, a Peruvian psychiatrist and an American anthro pologist ( a) review the literature on ayahuasca, a South American plant con taining Harmine, ( b) summarize earlier studies regarding its pharmacological and psychological effects, and ( c) describe its use in folk healing in Peru.
Abstract Background Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks’ functional organization. Even less is known on the neural correlates of subacute effects taking place days after the psychedelic experience. This study explores the subacute changes of primary sensory brain networks and networks supporting higher-order affective...
There has been resurgence of interest in the therapeutic use of serotonergic ("classic") psychedelics in major depressive disorder (MDD) and end-of-life distress. This commentary offers a critical appraisal of current evidence for antidepressant effects of classic psychedelics from contemporary clinical trials and highlights pitfalls that should be addressed before clinical translation. A...
Psychedelic drugs have recently emerged as plausibly effective pharmacological agents for the management of depression, anxiety, and other neuropsychiatric conditions, including those that are treatment-resistent. The latter half of the 20th century marked a revolution in the treatment of mental illnesses, exemplified by the introduction of selective serotonin reuptake inhibitors and other...
Maria Luiza Luiz Marçal, Luiz Antônio Sodré Costa
preprint
N,N-dimethyltryptamine (DMT) is an endogenous psychedelic tryptamine characterizedby a short duration of action due to its rapid metabolic degradation mediated by monoamineoxidase A (MAO-A), a flavoprotein that utilizes flavin adenine dinucleotide (FAD) as a redoxcofactor. When ingested as part of ayahuasca, a traditional Amazonian decoction containingPsychotria viridis (a source of DMT) and...
The public perception of psychedelic substances has become considerably more favorable in recent years. This shift can be seen in decriminalization measures passed in several U.S. cities as well as Oregon’s commitment to establish a state-licensed psilocybin-assisted psychotherapy program. These dramatic developments beg the question: Why now? Three particular aspects of psychedelic drugs have...
The law has long protected movement through physical space. This Article asks whether it should also protect movement through mental space. Psychedelics are reemerging in law and culture after decades of prohibition, but the prevailing justifications for reform--medical utility, religious freedom, neurodiversity, free speech, and especially cognitive liberty--either protect too few or fail to...
Introduction There is a growing and renewed interest in the use of hallucinogenic drugs in the treatment of psychiatric disorders, especially since the FDA approval of esketamine treatment for resistant depression. The response to hallucinogenic psychedelic substances (ayahuasca, psilocybin, LSD, ketamine) in the treatment of depression and addictions calls for a theoretical explanatory model....
Abstract Background: Due to increasing cultural and legal acceptance of psychedelics, there is a need to understand their potential influence on formal mental health care. This paper examines the connection between psychedelics, distress, and treatment utilization. Are psychedelic users less likely to use formal mental health care? Methods This study tests the relationship between psychedelics...