Therapy of existential distress of incurable patients is no less important task of palliative medicine than, in fact, relief ofphysical pain. At the same time, the unreliability of the means used in this field, noted by experts, forces us to pay attention to their al-ternative in the form of psychedelics-entheogens, whose therapeutic potential, judging by the content of world mythology, was...
OBJECTIVE Altered glutamatergic neurotransmission is implicated in the pathogenesis of major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA receptor antagonist and sigma-1 receptor agonist, which utilizes inhibition of CYP2D6 to increase its bioavailability. This phase 2 trial assessed the efficacy and safety of dextromethorphan-bupropion in the treatment of major...
BACKGROUND: The use of complementary and alternative medicine (CAM) has dramatically increased over the years since 1990. It is one of the fastest growing fields in healthcare and it is widely used today in the United States. Most people utilizing CAM approaches are seeking ways to improve overall health and well-being to relieve symptoms associated with body aches such as neck and back pain,...
Background: Mental health is a significant component of academic achievement, while psychological distress can reduce academic performance. Objectives: The present study aimed to investigate the effect of Mindfulness-based Cognitive Therapy (MBCT) on subjective well-being and psychological distress of Kerman University of Medical Sciences students. Methods: In this quasi-experimental study, the...
In recent years, work-related stress has grown exponentially and the negative impact that this condition has on people's health is considerable. The effects of work-related stress can be distinguished in those that affect workers (e.g., depression and anxiety) and those that affect the company (e.g., absenteeism and productivity). It is possible to distinguish two types of prevention...
One way to view mindfulness is the ability to become fully immersed in the present moment. Mindful awareness is being able to recognize thoughts, sounds, sensations, and emotions as they occur in the here and now. Mindfulness as a movement practice originated in the Far East and has become mainstream in today’s Western culture through popular meditative exercises such as yoga, tai chi, and...
This project is a systematic review that highlights how beneficial psychedelic psychotherapy can be to those suffering with mental illness. The three mental illnesses chosen to be analyzed in the literature were depression, post-traumatic stress disorder (PTSD), and anxiety. The drugs used in the specific articles included Psilocybin, Ayahuasca(DMT), and MDMA (3,4-methylenedioxymethamphetamine;...
Depression has long been recognized as a major public health problem.Fear and anxiety associated with the high morbidity and mortality of COVID-19 have increased risk factors for mental health decline.A high prevalence of psychiatric disorders has been documented in individuals who have been directly or indirectly exposed to life-threatening situations.Current evidence suggests decompensation...
In healthy adults, LSD produces little change in cognition, mood There have been numerous anecdotal reports of beneficial mood and cognitive effects from repeated administration of low doses of lysergic acid diethylamide (LSD) at intervals of 3 to 4 days, but few controlled studies have been conducted. Animal research has suggested that repeated low doses of LSD could confer antidepressant...
AbstractMDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, combined with psychotherapy has demonstrated efficacy for the treatment of chronic posttraumatic stress disorder (PTSD) patients. This controlled prospective study aimed to assess the bio-behavioral underpinnings of MDMA in a translational model of PTSD. Rats exposed to predator-scent stress (PSS) were...