ABSTRACT The present study aimed to characterize the relationship between mystical experience and psychopathology measures in a general-population sample of 763 U.S. adults. The participants were assessed across various domains including psychopathology, spirituality, personality, and life experience. The analysis revealed three distinct profiles among individuals: Transcendent Wellness,...
Results from clinical trials show that serotonergic psychedelics have efficacy in treating psychiatric disorders, where currently approved pharmacotherapies are inadequate. Developing psychedelic medicines, however, comes with unique challenges, such as tempering heightened anxiety associated with the psychedelic experience. We conceived a new strategy to potentially mitigate psychedelic...
Chronic diseases requiring long-term treatment, care, and follow-up can negatively affect the health and well-being of caregivers. Mindfulness-based interventions (MBIs) are increasingly used as a mental health intervention to control the psychological problems experienced by caregivers and improve their quality of life. This systematic review and meta-analysis aimed to provide evidence for a...
Brain and BehaviorOctober 1, 2024Najmeh Shahriyari, Shabnam Omidvar, Farideh Mohsenzadeh-Ledari et al.1 citation
With the spread of COVID-19, certain population groups, including pregnant women, were more susceptible than others. This disease can lead to postpartum complications, including mental disorders, in mothers. Few studies have investigated the impact of mindfulness-based interventions on mental health, and the most effective counseling approach to promote mental health has not been identified....
CureusOctober 1, 2024Priyadarsini Samanta, Ipsa Mohapatra, Rituparna Mitra et al.6 citations
In recent years, Internet Addiction Disorder (IAD) has become a major mental health concern among adolescents, with detrimental effects on social relationships, academic performance, and emotional well-being. The focus of mindfulness-based interventions (MBIs) on improving self-awareness, emotional regulation, and cognitive flexibility has drawn interest in MBIs as possible therapeutic...
Major depressive disorder is a multifactorial disorder that originates from a complex web of variables and overlaps with similar disorders (e.g., depression and anxiety). As such, animal models should account for the considerable symptom overlap between psychiatric disorders. We sought to extend the findings of behavioral assays that encompass both anxiety and stress/depression components. To...
Each year, 3-4% of the global population experiences post-traumatic stress disorder (PTSD), a chronic mental disorder with significant social and economic repercussions. Although it has been shown that ketamine can effectively alleviate PTSD symptoms in individuals, the specific mechanism of action underlying its anti-PTSD effects remains unclear. In this study, we investigated how a single,...
Standard antidepressant treatments often take weeks to reach efficacy and are ineffective for many patients. (R,S)-ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to be a rapid-acting antidepressant and to decrease depressive symptoms within hours of administration. While previous studies have shown the importance of the GluN2B subunit of the NMDA receptor on...
Introduction. High levels of anxiety are often associated with abnormal activity in the brain areas involved in emotional processing, cognitive control, and reduced connectivity in the default mode network (DMN). Studies also show that the activation of the DMN increases during self-reflection processes, especially positive self-reference, suggesting the possibility of using self-reflection to...
How is language related to consciousness? Language functions to categorise perceptual experiences (e.g., labelling interoceptive states as 'happy') and higher-level constructs (e.g., using 'I' to represent the narrative self). Psychedelic use and meditation might be described as altered states that impair or intentionally modify the capacity for linguistic categorisation. For example,...