Addiction: all studies (page 472) - The Consciousness Library

Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity.

Biochemistry January 21, 2022 David E. Olson 121 citations

In addition to producing profound subjective effects following acute administration, psychedelic compounds can induce beneficial behavioral changes relevant to the treatment of neuropsychiatric disorders that last long after the compounds have been cleared from the body. One hypothesis with the potential to explain the remarkable enduring effects of psychedelics is related to their abilities to...

DOI: 10.1021/acs.biochem.1c00812 Full text

Psychotherapeutic Techniques for Distressing Memories: A Comparative Study between EMDR, Brainspotting, and Body Scan Meditation

International Journal of Environmental Research and Public Health January 20, 2022 Fabio D’Antoni, Alessio Matiz, Franco Fabbro et al.

Objectives: We explored the effects of a single 40-min session of Eye Movement Desensitization and Reprocessing (EMDR), Brainspotting (BSP), and Body Scan Meditation (BSM) in the processing of distressing memories reported by a non-clinical sample of adult participants. Design: A within-subject design was used. Methods: Participants (n = 40 Psychologists/MDs) reported four distressing memories,...

DOI: 10.3390/ijerph19031142

Human Cortical Serotonin 2A Receptor Occupancy by Psilocybin Measured Using [11C]MDL 100,907 Dynamic PET and a Resting-State fMRI-Based Brain Parcellation

Frontiers in Neuroergonomics January 20, 2022 Yun Zhou, Frederick S. Barrett, Theresa M. Carbonaro et al. 17 citations

Psilocybin (a serotonin 2A, or 5-HT 2A , receptor agonist) has shown preliminary efficacy as a treatment for mood and substance use disorders. The current report utilized positron emission tomography (PET) with the selective 5-HT 2A receptor inverse agonist radioligand [ 11 C]MDL 100,907 (a.k.a. M100,907) and cortical regions of interest (ROIs) derived from resting-state functional...

DOI: 10.3389/fnrgo.2021.784576 Psilocybin Serotonin Default mode network Radioligand +5

The Need for Psychedelic-Assisted Therapy in the Black Community and the Burdens of Its Provision

Frontiers in Psychiatry January 20, 2022 Darron T. Smith, Sonya C. Faber, NiCole T. Buchanan et al. 69 citations

Psychedelic medicine is an emerging field that examines entheogens, psychoactive substances that produce non-ordinary states of consciousness (NOSC). 3,4-methylenedioxymethamphetamine (MDMA) is currently in phase-3 FDA clinical trials in the United States (US) and Canada to treat the symptoms of posttraumatic stress disorder (PTSD). MDMA is used in conjunction with manualized therapy, because...

DOI: 10.3389/fpsyt.2021.774736 Psychotherapist

COVID-19 on mind: Daily worry about the coronavirus is linked to negative affect experienced during mind-wandering and dreaming

January 18, 2022 Pilleriin Sikka, Jarno Tuominen, Alejandro Ezquerro‐Nassar et al. 2 citations preprint

Despite a surge of studies on the effects of COVID-19 on our well-being, we know little about how the pandemic is reflected in people’s spontaneous thoughts and experiences, such as mind-wandering (or daydreaming) during wakefulness and dreaming during sleep. We investigated whether and how COVID-19 related general concern, anxiety, and daily worry are associated with the daily fluctuation of...

DOI: 10.31234/osf.io/bk4tn Full text

Clonidine Use for the Treatment of Nightmares in Posttraumatic Stress Disorder.

Case Reports in Psychiatry January 17, 2022 Jill S Bange, Kelly E Melvin

Introduction: While clonidine is used clinically for the treatment of nightmares in posttraumatic stress disorder (PTSD), few case reports demonstrating this indication exist, and there have been few studies investigating clonidine's mechanism of action for controlling nightmare symptoms. Case Report. In order to further characterize clonidine's role in treating nightmare symptoms in PTSD, we...

DOI: 10.1155/2022/5251406 Full text

Default Mode Network and Neural Phase Synchronization in Healthy Aging: A Resting State EEG Study

Neuroscience January 17, 2022 Ricky Chow, Rahel Rabi, Shahier Paracha et al. 23 citations

Aging is associated with altered brain connectivity within the default mode network (DMN). Although research using functional magnetic resonance imaging has quantified age-related alterations in functional connectivity within this network during resting state, it is less clear how this may be reflected in electrophysiological measures, and how this relates to cognitive performance in older...

DOI: 10.1016/j.neuroscience.2022.01.008 Default mode network Electroencephalography Phase synchronization Resting State FMRI +4

A Cohort-Based Case Report: The Impact of Ketamine-Assisted Therapy Embedded in a Community of Practice Framework for Healthcare Providers With PTSD and Depression

Frontiers in Psychiatry January 12, 2022 Shannon Dames, Pamela Kryskow, Crosbie Watler 38 citations

Amid an international pandemic and a worsening mental health crisis, ketamine-assisted therapy is emerging as a promising solution for those deemed “treatment resistant.” Post-traumatic stress disorder (PTSD) and depression are on the rise, with accelerating direct (e.g., burden of suffering) and indirect (e.g., disability/role impairment and impact on family) costs. Psychedelic-assisted...

DOI: 10.3389/fpsyt.2021.803279 Full text Psychedelic therapy Depression Ketamine-assisted psychotherapy Healthcare providers hcp +6

Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3

Molecular Psychiatry January 10, 2022 Xiu-Li Zhao, Annika B. Ozols, K. Meyers et al.

Serotonin 2A receptors (5-HT2ARs) mediate the hallucinogenic effects of psychedelic drugs and are a key target of the leading class of medications used to treat psychotic disorders. These findings suggest that dysfunction of 5-HT2ARs may contribute to the symptoms of schizophrenia, a mental illness characterized by perceptual and cognitive disturbances. Indeed, numerous studies have found that...

DOI: 10.1038/s41380-021-01390-w Full text

Guanosine boosts the fast, but not sustained, antidepressant-like and pro-synaptogenic effects of ketamine by stimulating mTORC1-driven signaling pathway.

European Neuropsychopharmacology January 7, 2022 A. Camargo, A. P. Dalmagro, Eslen Delanogare et al.

The mTORC1-dependent dendritic spines formation represents a key mechanism for fast and long-lasting antidepressant responses, but it remains to be determined whether this mechanism may account for the ability of guanosine in potentiating ketamine's actions. Here, we investigated the ability of ketamine plus guanosine to elicit fast and sustained antidepressant-like and pro-synaptogenic effects...

DOI: 10.1016/j.euroneuro.2021.12.010