Neuroscience Letters
January 18, 2024
Hector Vargas-Perez, Fernando Minauro-Sanmiguel, Ryan Ting-A-Kee et al.
2 citations
According to the opponent-process theory of drug addiction, the intake of an addictive substance initiates two processes: a rapid primary process that results in the drug's rewarding effects, and a slower opponent process that leads to the aversive motivational state of drug aftereffects. This aversive state is integral in the desire, pursuit, and maintenance of drug use, potentially leading to...
Frontiers in Psychiatry
January 8, 2024
N. Jones, Laura M. Wagner, Molly C. Pellitteri Hahn et al.
10 citations
Introduction The use of the psychedelic compound psilocybin in conjunction with psychotherapy has shown promising results in the treatment of psychiatric disorders, though the underlying mechanisms supporting these effects remain unclear. Psilocybin is a Schedule I substance that is dephosphorylated in vivo to form an active metabolite, psilocin. Psilacetin, also known as O-acetylpsilocin or...
Current Neuropharmacology
January 5, 2024
Tamar Glatman Zaretsky, Kathleen M. Jagodnik, Robert Barsic et al.
73 citations
Abstract: Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estimated 12 million U.S. adults are presently affected by this disorder. Current treatments include psychological therapies (e.g., exposure-based interventions) and pharmacological treatments (e.g., selective serotonin reuptake inhibitors (SSRIs))....
Elife
January 5, 2024
Daniel Toker, Eli J Müller, Hiroyuki Miyamoto et al.
21 citations
Consciousness is thought to be regulated by bidirectional information transfer between the cortex and thalamus, but the nature of this bidirectional communication - and its possible disruption in unconsciousness - remains poorly understood. Here, we present two main findings elucidating mechanisms of corticothalamic information transfer during conscious states. First, we identify a highly...
International Journal of Pharmacognosy and Life Science
2024
Eduardo Tavares
The tryptamine-rich shrub Psychotria viridis stands at the centre of Amazonian ethnobotany, yet baseline data on its full alkaloid profile remain surprisingly thin. This research characterized alkaloid diversity in leaf extracts from five wild understory populations growing on terra firme soils within a 60-km radius of Manaus, Amazonas State, Brazil. Leaves were collected during the wet season...
2024
Johannes Tobias Reckweg
The research described in this thesis focused on the psychedelic and psychoactive effects of the psychedelic drug Mebufotenin (5-MeO-DMT), as well as its safety and therapeutic efficacy. A prominent feature of 5-MeO-DMT is its ability to elicit a psychedelic state, which has been linked to feelings of profoundness and meaningfulness. This state, sometimes referred to as a mystical or peak...
Acta Amazonica
2024
Salvana Priscylla Manso Costa, Keith Cardoso Carvalho, Isabella Nunes Gomes et al.
4 citations
ABSTRACT Ayahuasca is a psychoactive decoction originally used in indigenous Amazonian culture. It consists of a dense brown liquid that most frequently results from the decoction of two plants native to the Amazon rainforest, Psychotria viridis (Rubiaceae) and Banisteriopsis caapi (Malpighiaceae). The composition of the decoction is variable, as several plant species can be used in its...
Journal of Psychopharmacology
2024
Lisa Luan, Emma Eckernäs, Michael Ashton et al.
41 citations
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that induces a rapid and transient altered state of consciousness when inhaled or injected via bolus administration. Its marked and novel subjective effects make DMT a powerful tool for the neuroscientific study of consciousness and preliminary results show its potential role in treating mental health conditions. In a within-subjects,...
Expert Review of Clinical Pharmacology
2024
Lucas F Borkel, Jaime Rojas-Hernández, Luis Alberto Henríquez-Hernández et al.
40 citations
In psychedelic therapy, the importance of set and setting is a fundamental but under-researched assumption. The aim of this study is to correlate variables of set (psychedelic use motivation) and setting (psychedelic use location and type of companion) with psychopathology, wellbeing and personality variables. A sample of 1022 participants of the Spanish-speaking population was collected...
Military psychology : the official journal of the Division of Military Psychology, American Psychological Association
2024
Stacey B. Armstrong, Yitong Xin, Nathan D. Sepeda et al.
19 citations
This study evaluated prospective associations of ibogaine and 5-MeO-DMT treatment for risky alcohol use and post-traumatic stress disorder (PTSD) symptoms among United States (US) Special Operations Forces Veterans (SOFV). Data were collected during standard clinical operations at pre-treatment and 1-month (1 m), 3-months (3 m), and 6-months (6 m) post-treatment in an ibogaine and 5-MeO-DMT...