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Molly C. Pellitteri Hahn

2 papers in the library · 17 citations · publishing 2024

Papers

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Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT).

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences August 1, 2024 Christopher G Witowski, Mika R Hess, Nate T Jones et al. 7 citations

There is considerable evidence from the literature that psychedelics, such as N,N-dimethyltryptamine (DMT), are safe and effective treatments for depression. However, clinical administration to induce psychedelic effects and expensive psychotherapy-assisted treatments likely limit accessibility to the average patient. There is emerging evidence that DMT promotes positive behavioral changes in...

In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybin

Frontiers in Psychiatry January 8, 2024 N. Jones, Laura M. Wagner, Molly C. Pellitteri Hahn et al. 10 citations

Introduction The use of the psychedelic compound psilocybin in conjunction with psychotherapy has shown promising results in the treatment of psychiatric disorders, though the underlying mechanisms supporting these effects remain unclear. Psilocybin is a Schedule I substance that is dephosphorylated in vivo to form an active metabolite, psilocin. Psilacetin, also known as O-acetylpsilocin or...