Effects of MDA upon differential serial compound conditioning and reflex modification of the rabbit's nictitating membrane response.
K Kirkpatrick-Steger, S Vander Linden, I Gormezano
Pharmacology, Biochemistry, and Behavior February 1992 DOI: 10.1016/0091-3057(92)90107-q (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal conditioning experiment Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | 3 4-methylenedioxyamphetamine (MDA) |
| Key findings | MDA reduced differential conditioned responding to two serial compound stimuli and their distinctive components while enhancing conditioned responding to the shared component. It also attenuated reflex modification by the compounds and distinctive components but facilitated reflex modification to the shared component alone. The authors conclude MDA alters the intensity, distinctiveness, and persistence of stimulus representations. |
Abstract
The present investigations sought to determine the effects of 3,4-methylenedioxyamphetamine (MDA) on: 1) differential conditioning of the rabbit's nictitating membrane response to the serial compounds A-X-US (tone-light-reinforced compound) and B-X (white noise-light-unreinforced compound) by examining differential responding to A and B and their conditional control over responding to X within the compounds (Experiment 1); and 2) the ability of the compound stimuli and their components to modify the amplitude of the unconditioned nictitating membrane response (Experiment 2). Experiment 1 revealed that MDA decremented differential responding to the serial compounds and their A and B components, while enhancing conditioned responding to the X component. In addition, Experiment 2 indicated that MDA attenuated reflex modification to the compounds and their A and B components, but facilitated reflex modification to X alone. The results of these experiments indicated that MDA operated to alter the intensity, distinctiveness, and persistence (short-term memory) of stimulus representations.
Citations in the library
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