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Heyneanine hydroxyindolenine, a new indole alkaloid from Ervatamia coronaria var. plena.

P Sharma, G A Cordell

Journal of Natural Products May 1, 1988 DOI: 10.1021/np50057a012 (opens in new tab)

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Characteristics Phytochemical isolation and structural elucidation study Peer reviewed
Topics Ibogaine
Keywords Plants, medicinal Terpenes Alkaloids Plant extracts Magnetic resonance spectroscopy Thailand
Key points The authors report isolating a new indole alkaloid, 19S-heyneanine hydroxyindolenine, from Ervatamia coronaria var. plena and determining its structure from spectral data. Nine known alkaloids and six common triterpenoids were also isolated, and coronaridine is described as the principal cytotoxic alkaloid obtained.

Abstract

The whole plant of Ervatamia coronaria var. plena obtained from Thailand has afforded a new indole alkaloid 19S-heyneanine hydroxyindolenine whose structure was deduced through interpretation of spectral data. Nine known alkaloids, coronaridine, coronaridine hydroxyindolenine, voacangine, voacangine hydroxyindolenine, heyneanine, voacristine, 3-oxo-coronaridine, 3-oxo-voacangine,and voacristine hydroxyindolenine, and six common triterpenoids were also isolated. Coronaridine was the principal cytotoxic alkaloid obtained.

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