Brain Mechanisms of Altered Consciousness in Generalised Seizures
Stefano Seri, Daniela Brazzo, Ngoc Jade Thai, Antonella Cerquiglini
Behavioural Neurology 2011 DOI: 10.1155/2011/491957 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Altered states of consciousness |
| Citations | 17 |
| Key points | Argues that impaired consciousness in generalized seizures involves disruption of the default state network, including fronto-parietal cortices, and that subcortical activation of thalamocortical structures and striate nuclei is also crucial to this impairment. |
Abstract
In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.
Citations in the library
Cited by 2
Cites 4
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Consciousness, epilepsy, and emotional qualia. Epilepsy & Behavior September 2005
- Why do seizures cause loss of consciousness? The Neuroscientist October 2003
- A framework for consciousness Nature Neuroscience February 1, 2003