Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM)
Katherine M. Serafine, C. France
Behavioural Pharmacology February 1, 2014 DOI: 10.1097/fbp.0000000000000015 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study in rats (diet manipulation with drug dose–response testing) Peer reviewed |
|---|---|
| Sample size | 15 |
| Population | Male Sprague–Dawley rats fed high-fat (n=8) or standard (n=7) chow |
| Interventions | Quinpirole High-fat chow Standard chow |
| Dose | DOM 0.1–3.2 mg/kg; quinpirole 0.0032–0.32 mg/kg |
| Duration | 11 weeks free access followed by 6 weeks restricted access |
| Measures | DOM-induced head twitch, quinpirole-induced yawning |
| Topics | Serotonin |
| Key findings | Free access to high-fat chow increased sensitivity to quinpirole-induced yawning but did not alter DOM-induced head twitch. Restricting access to either diet shifted the DOM head-twitch dose–response curve to the right and the quinpirole yawning curve downward in both groups. The authors argue that feeding conditions affect sensitivity to drugs acting on serotonin and dopamine systems, possibly influencing abuse vulnerability and therapeutic effectiveness. |
Abstract
Feeding conditions can impact sensitivity to drugs acting on dopamine receptors; less is known about the impact of feeding conditions on the effects of drugs acting on serotonin (5-HT) receptors. This study examined the effects of feeding conditions on sensitivity to the direct-acting 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 0.1–3.2 mg/kg) and the direct-acting dopamine D3/D2 receptor agonist quinpirole (0.0032–0.32 mg/kg). Male Sprague–Dawley rats had free access (11 weeks), followed by restricted access (6 weeks), to high fat (34.3%, n=8) or standard (5.7% fat; n=7) chow. Rats eating high fat chow became insulin resistant and gained more weight than rats eating standard chow. Free access to high fat chow did not alter sensitivity to DOM-induced head twitch but increased sensitivity to quinpirole-induced yawning. Restricting access to high fat or standard chow shifted the DOM-induced head twitch dose–response curve to the right and shifted the quinpirole-induced yawning dose–response curve downward in both groups of rats. Some drugs of abuse and many therapeutic drugs act on 5-HT and dopamine systems; these results show that feeding conditions impact sensitivity to drugs acting on these systems, thereby possibly affecting vulnerability to abuse, as well as the therapeutic effectiveness of drugs.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 2
- Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice Frontiers in Pharmacology February 6, 2018
- Evaluation of potential punishing effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rhesus monkeys responding under a choice procedure. Behavioural Pharmacology October 1, 2024
Cites 2
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