Mindfulness combined with cognitive motor dual task training in Parkinson’s disease with mild cognitive impairment
Rui Wang, Jing-Zhi Zhang, Si-Mao Xu, Jun Chen, Ben-xiang He
iScience May 30, 2026 DOI: 10.1016/j.isci.2026.116197 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Single-blind randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 53 |
| Population | Patients with Parkinson's disease and mild cognitive impairment (PD-MCI) |
| Intervention | aerobic training |
| Duration | 4 weeks |
| Topics | Meditation |
| Key findings | Mindfulness combined with cognitive-motor dual-task training produced greater improvements than CMDT alone or aerobic training in global cognitive function, motor symptoms, depression, sleep quality, quality of life, and postural stability after 4 weeks. The authors argue this supports a multimodal rehabilitation strategy targeting cognitive, motor, and neuropsychiatric pathways in PD-MCI. |
Abstract
Summary Parkinson’s disease with mild cognitive impairment (PD-MCI) is a common non-motor manifestation that severely impairs functional independence and quality of life. A single-blind randomized controlled trial was conducted to evaluate whether mindfulness combined with cognitive-motor dual-task training (CMDT) improves multidimensional outcomes in patients with PD-MCI. Fifty three participants were randomly assigned to mindfulness plus CMDT, CMDT alone, or aerobic training for 4 weeks. Compared with the other groups, the combined intervention produced greater improvements in global cognitive function, motor symptoms, depression, sleep quality, quality of life, and postural stability. These findings support a multimodal rehabilitation strategy that simultaneously targets cognitive, motor, and neuropsychiatric pathways in PD-MCI.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cites 14
- Mechanisms of mindfulness Journal of Clinical Psychology December 29, 2005
- Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances JAMA Internal Medicine February 16, 2015
- Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis. Neuroscience & Biobehavioral Reviews February 22, 2022
- The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Systematic Review and Meta-analysis Neuropsychology Review August 4, 2021
- A mindfulness meditation mobile app improves depression and anxiety in adults with sleep disturbance: Analysis from a randomized controlled trial General Hospital Psychiatry September 11, 2021
and 9 more in the library