Comparison of cognitive behavioral and mindfulness meditation interventions on adaptation to rheumatoid arthritis for patients with and without history of recurrent depression.
Alex J Zautra, Mary C Davis, John W Reich, Perry Nicassario, Howard Tennen, Patrick H. Finan, Anna Kratz, Brendt Parrish, Michael R. Irwin
Journal of Consulting and Clinical Psychology June 2008 DOI: 10.1037/0022-006x.76.3.408 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 144 |
| Population | Adults with rheumatoid arthritis |
| Interventions | cognitive behavioral therapy for pain mindfulness meditation and emotion regulation therapy education-only group |
| Topics | Depression Meditation |
| Key findings | Cognitive behavioral therapy for pain produced the greatest improvement in self-reported pain control and reductions in interleukin-6, while both cognitive behavioral therapy and mindfulness meditation improved coping efficacy more than education-only. Patients with recurrent depression benefited most from mindfulness meditation and emotion regulation therapy across several measures, including affect and physicians' ratings of joint tenderness. |
Abstract
This research examined whether cognitive behavioral therapy and mindfulness interventions that target responses to chronic stress, pain, and depression reduce pain and improve the quality of everyday life for adults with rheumatoid arthritis (RA). The 144 RA participants were clustered into groups of 6-10 participants and randomly assigned to 1 of 3 treatments: cognitive behavioral therapy for pain (P); mindfulness meditation and emotion regulation therapy (M); or education-only group (E), which served as an attention placebo control. The authors took a multimethod approach, employing daily diaries and laboratory assessment of pain and mitogen-stimulated levels of interleukin-6 (IL-6), a proinflammatory cytokine. Participants receiving P showed the greatest Pre to Post improvement in self-reported pain control and reductions in the IL-6; both P and M groups showed more improvement in coping efficacy than did the E group. The relative value of the treatments varied as a function of depression history. RA patients with recurrent depression benefited most from M across several measures, including negative and positive affect and physicians' ratings of joint tenderness, indicating that the emotion regulation aspects of that treatment were most beneficial to those with chronic depressive features.
Comparable studies
Other randomized controlled trials on depression, most cited first.
Citations in the library
Cited by 69
- Mindfulness Interventions Annual Review of Psychology September 30, 2016
- Mindfulness‐Based Stress Reduction and Mindfulness‐Based Cognitive Therapy – a systematic review of randomized controlled trials Acta Psychiatrica Scandinavica April 28, 2011
- A systematic review of neurobiological and clinical features of mindfulness meditations Psychological Medicine November 27, 2009
- Mindfulness Meditation for Substance Use Disorders: A Systematic Review Substance Abuse October 1, 2009
- How mindfulness training promotes positive emotions: Dismantling acceptance skills training in two randomized controlled trials. Journal of Personality and Social Psychology December 1, 2018
and 64 more in the library
Cites 6
- Mindfulness training as a clinical intervention: A conceptual and empirical review. Clinical Psychology Science and Practice 2003
- Mechanisms of mindfulness Journal of Clinical Psychology December 29, 2005
- Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Journal of Consulting and Clinical Psychology 2000
- Metacognitive awareness and prevention of relapse in depression: Empirical evidence. Journal of Consulting and Clinical Psychology 2002
- What Do We Really Know About Mindfulness-Based Stress Reduction? Psychosomatic Medicine 2002
and 1 more in the library