Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats.
Marie-Claude Audet, Sonia Goulet, François Y Doré
Behavioural Brain Research January 25, 2007 DOI: 10.1016/j.bbr.2006.10.017 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | PCP |
| Dose | 5 mg/kg bid for 7 days |
| Duration | 7-day treatment, tested one week after withdrawal |
| Topics | Anxiety |
| Key findings | Rats treated with 5 mg/kg PCP twice daily for 7 days showed increased anxiety-like behavior one week after withdrawal: less time in the lit area of a light/dark apparatus and fewer contacts with a cat collar. The authors argue this pattern resembles the distorted emotional experience in human schizophrenia. |
Abstract
Anxiety was assessed in rats treated with 5mg/kg of PCP bid for 7 days. One week after withdrawal, measures were collected in the light/dark apparatus and during exposure to a cat odor. PCP decreased time spent in the lit area and number of contacts with a cat collar. PCP thus amplified rats' fear of unprotected environments and predatory threats, which seems compatible with the distorted emotional experience in human schizophrenia.
Comparable studies
Other preclinical and animal studies on anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Rats | 2020 | Preclinical study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Chronic, Intermittent Microdoses of the Psychedelic N , N -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents Male rats | 2019 | Animal study | |
| 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning Mice | 2015 | Preclinical experimental study | |
| Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline Male mice exposed to chronic restraint stress | 2022 | Preclinical experimental study |
Citations in the library
Cited by 6
- Male rats treated with subchronic PCP show intact olfaction and enhanced interest for a social odour in the olfactory habituation/dishabituation test Behavioural Brain Research June 1, 2018
- The effects of phencyclidine (PCP) on anxiety-like behavior in the elevated plus maze and the light-dark exploration test are age dependent, sexually dimorphic, and task dependent. Pharmacology, Biochemistry, and Behavior November 1, 2011
- Inhibition of fatty acid amide hydrolase modulates anxiety-like behavior in PCP-treated rats. Pharmacology, Biochemistry, and Behavior June 2011
- Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field. Journal of Psychopharmacology May 2010
- Phencyclidine (PCP) produces sexually dimorphic effects on voluntary sucrose consumption and elevated plus maze behavior. Pharmacology, Biochemistry, and Behavior April 2010
and 1 more in the library
Cites 3
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- Delayed alternation performance following subchronic phencyclidine administration in rats depends on task parameters. Progress in Neuro-Psychopharmacology and Biological Psychiatry June 30, 2007
- Transient hypolocomotion in rats repeatedly exposed to phencyclidine: an appraisal of motor function and motivation. Progress in neuro-psychopharmacology & biological psychiatry January 30, 2007