Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field.
S L McLean, M L Woolley, J C Neill
Journal of Psychopharmacology May 2010 DOI: 10.1177/0269881109103112 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 40 |
| Population | Female hooded-Lister rats |
| Intervention | Phencyclidine (PCP) |
| Dose | 2 mg/kg |
| Duration | 7-day treatment followed by a 7-day washout |
| Measures | Elevated plus maze, open field |
| Key findings | Subchronic phencyclidine (2 mg/kg twice daily for 7 days) did not significantly affect behavior on the elevated plus maze or in the open field in female hooded-Lister rats, leading the authors to conclude that subchronic PCP does not induce anxiety-like behavior. |
Abstract
Female hooded-Lister rats received either subchronic phencyclidine (PCP) (2 mg/kg, n = 20) or vehicle (1 ml/kg, n = 20) intraperitoneally twice daily for 7 days, followed by a 7-day washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the subchronic PCP-treated rats. Rats were then tested on the elevated plus maze and in an open field for 10 min. Subchronic PCP did not significantly affect behaviour on the elevated plus maze or in the open field. In conclusion, subchronic PCP does not induce anxiety-like behaviour.
Citations in the library
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- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2012
- Male rats treated with subchronic PCP show intact olfaction and enhanced interest for a social odour in the olfactory habituation/dishabituation test Behavioural Brain Research June 1, 2018
- Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia Behavioural Pharmacology October 1, 2017
- Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system. European Neuropsychopharmacology February 2016
- The effects of phencyclidine (PCP) on anxiety-like behavior in the elevated plus maze and the light-dark exploration test are age dependent, sexually dimorphic, and task dependent. Pharmacology, Biochemistry, and Behavior November 1, 2011
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Cites 7
- Recent advances in the phencyclidine model of schizophrenia American Journal of Psychiatry October 1, 1991
- Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation. Behavioural Brain Research March 5, 2008
- Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction study. Progress in Neuro-Psychopharmacology and Biological Psychiatry February 15, 2008
- Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats. Behavioural Brain Research January 25, 2007
- The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm. Behavioural Brain Research May 15, 2006
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