Inhibition of fatty acid amide hydrolase modulates anxiety-like behavior in PCP-treated rats.
Alexandre Seillier, Andrea Giuffrida
Pharmacology, Biochemistry, and Behavior June 2011 DOI: 10.1016/j.pbb.2011.03.010 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Population | Rats treated with saline or sub-chronic PCP |
| Interventions | PCP URB597 AM251 |
| Measures | Elevated-Plus-Maze |
| Topics | Anxiety |
| Key points | Sub-chronic PCP produced a CB(1)-dependent decrease in anxiety-like behavior in the Elevated-Plus-Maze, which URB597 reversed in a CB(1)-independent manner since AM251 did not block the reversal. The authors suggest PCP-treated rats have altered endocannabinoid transmission and that anxiety does not contribute to PCP-induced social withdrawal. |
Abstract
Sub-chronic administration of PCP produces a social interaction deficit that is reversed by URB597, an inhibitor of the catabolic enzyme of the endocannabinoid anandamide. Since increased anxiety may contribute to social withdrawal and URB597 has been shown to have an anxiolytic action, we studied whether this drug affected saline- and PCP-treated rats' performance in the Elevated-Plus-Maze task, which has been used to assess anxiety-like effects. Sub-chronic PCP produced a CB(1)-dependent decrease in anxiety-like behavior that was reversed by URB597 in a CB(1)-independent fashion, as it was not blocked by the CB(1) antagonist AM251. These findings suggest that PCP-treated rats have altered endocannabinoid transmission and that anxiety does not contribute to the PCP-induced social withdrawal.
Comparable studies
Other preclinical and animal studies on anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Rats | 2020 | Preclinical study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Chronic, Intermittent Microdoses of the Psychedelic N , N -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents Male rats | 2019 | Animal study | |
| 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning Mice | 2015 | Preclinical experimental study | |
| Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline Male mice exposed to chronic restraint stress | 2022 | Preclinical experimental study |
Citations in the library
Cited by 5
- Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model. PLoS One 2020
- Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia Behavioural Pharmacology October 1, 2017
- Distinct neuronal activation patterns are associated with PCP-induced social withdrawal and its reversal by the endocannabinoid-enhancing drug URB597 Neurosciences research April 19, 2016
- Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system. European Neuropsychopharmacology February 2016
- Effects of Endocannabinoid System Modulation on Cognitive and Emotional Behavior Frontiers in Behavioral Neuroscience July 22, 2011
Cites 6
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- CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour. Neuropharmacology January 2008
- Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis. Methods and findings in experimental and clinical pharmacology May 1, 2007
- Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats. Behavioural Brain Research January 25, 2007
and 1 more in the library