Improvement of phencyclidine-induced social behaviour deficits in rats: involvement of 5-HT1A receptors.
Shikha Snigdha, Joanna C. Neill
Behavioural Brain Research August 5, 2008 DOI: 10.1016/j.bbr.2008.03.018 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Sample size | 58 |
| Population | Female hooded-Lister rats |
| Interventions | Phencyclidine (PCP) Aripiprazole WAY100635 Fluoxetine Chlordiazepoxide (CDP) |
| Dose | PCP 2 mg/kg i.p. twice daily; aripiprazole 5 mg/kg s.c.; WAY100635 0.5 mg/kg i.p.; fluoxetine 2.5 mg/kg i.p.; chlordiazepoxide 2.5 mg/kg i.p. |
| Duration | 7-day PCP treatment followed by a 7-day washout; acute drug treatment 30 min prior to testing |
| Topics | Serotonin |
| Key points | PCP-induced social behaviour deficits in female rats were reversed by acute aripiprazole and fluoxetine but not by chlordiazepoxide or WAY100635, and WAY100635 pre-treatment blocked aripiprazole's reversal effect. The authors suggest these drug effects may involve the serotonergic system, particularly 5-HT1A receptors. |
Abstract
We have recently shown that sub-chronic phencyclidine (PCP) treatment produces social behaviour deficits in female rats which are reversed by ziprasidone but not haloperidol or clozapine. This investigation was designed to extend the previous findings and identify the role of 5-HT(1A) receptors in mediating the effects of these drugs in this model. Female hooded-Lister rats received vehicle (n=36; intraperitoneal (i.p.)) or PCP (n=22; 2mg/kg, i.p.) twice daily for 7 days, followed by a 7-day washout period. On test days, PCP-treated rats were treated acutely with aripiprazole (5mg/kg, s.c.) or WAY100635 (0.5mg/kg, i.p.) alone and in combination. In a second experiment, PCP-treated rats were treated acutely with either fluoxetine (2.5mg/kg, i.p.) or chlordiazepoxide (CDP) (2.5mg/kg, i.p.) all 30 min prior to testing. For the test, pairs of unfamiliar rats receiving acute doses of drugs described above were placed in the test arena and social behaviours (following, sniffing, climbing over and under, exploration of inanimate object and avoiding) were recorded on video for subsequent blind scoring. The results showed that PCP-induced deficits in social behaviours were reversed by acute treatment with both aripiprazole and fluoxetine but not CDP or WAY100635. Furthermore, pre-treatment with WAY100635 prevented the reversal of social behaviour deficits observed with aripiprazole. These findings suggest that the beneficial effects of drugs such as aripiprazole and fluoxetine on PCP-induced social behaviour deficits, a potential model of negative symptoms of schizophrenia, may be a consequence of modifications of the serotonergic system, in particular through an interaction with 5-HT(1A) receptors.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 8
- Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats Psychopharmacology April 1, 2019
- Multidimensional analysis of social withdrawal in the sub-chronic phencyclidine rat model for schizophrenia. Psychopharmacology April 23, 2026
- Male rats treated with subchronic PCP show intact olfaction and enhanced interest for a social odour in the olfactory habituation/dishabituation test Behavioural Brain Research June 1, 2018
- Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia Behavioural Pharmacology October 1, 2017
- Disruption of social cognition in the sub-chronic PCP rat model of schizophrenia: Possible involvement of the endocannabinoid system. European Neuropsychopharmacology February 2016
and 3 more in the library
Cites 3
- Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation. Behavioural Brain Research March 5, 2008
- Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions. International review of neurobiology 2007
- Fluoxetine prevents PCP- and MK801-induced HSP70 expression in injured limbic cortical neurons of rats. Biological Psychiatry May 1, 2000