Chemical methods for the synthesis and modification of neoclerodane diterpenes.
Anthony Lozama, Thomas E Prisinzano
Bioorganic & Medicinal Chemistry Letters September 15, 2009 DOI: 10.1016/j.bmcl.2009.07.069 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Key findings | The review surveys the chemical methods used to modify and synthesize the neoclerodane diterpene salvinorin A, a compound that has attracted interest because of its unusual pharmacological profile. It notes that although several neoclerodane diterpenes show biological activity, only a limited number of chemical investigations of this class have been conducted. |
Abstract
Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.
Citations in the library
Cited by 6
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- From local to global-fifty years of research on Salvia divinorum. Journal of Ethnopharmacology February 3, 2014
- Semisynthetic neoclerodanes as kappa opioid receptor probes. Bioorganic & Medicinal Chemistry May 1, 2012
- Synthesis of neoclerodane diterpenes and their pharmacological effects. Topics in current chemistry 2011
- Preparation of neoclerodane diterpenes as probes for the opioid receptor system July 1, 2010
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