Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands.
Wayne W Harding, Kevin Tidgewell, Nathan Byrd, Howard Cobb, Christina M Dersch, Eduardo R Butelman, Richard B Rothman, Thomas E Prisinzano
Journal of Medicinal Chemistry July 28, 2005 DOI: 10.1021/jm048963m (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Key points | Reports the synthesis of a nonnitrogenous neoclerodane diterpene (compound 13) that has mu opioid receptor affinity and acts as an agonist at mu opioid receptors, which the authors present as the identification of a novel structural class of mu opioid receptor agonists. |
Abstract
Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with mu opioid receptor affinity (13) that is an agonist at mu opioid receptors. This represents the identification of a novel structural class of mu opioid receptor agonists.
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