Side effects of microdosing lysergic acid diethylamide and psilocybin: A systematic review of potential physiological and psychiatric outcomes
Stefan Modzelewski, Anna Stankiewicz, Napoleon Waszkiewicz, Kacper Łukasiewicz
Neuropharmacology March 7, 2025 DOI: 10.1016/j.neuropharm.2025.110402 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD Microdosing Psilocybin |
| Keywords | Adverse reactions Side effects Psychedelics hallucinogens Microdosing sub-perceptual dosing Entheogens |
| Citations | 5 |
| Key findings | Heterogeneity in reporting side effects and short study durations limit current psychedelic research, and future studies should transparently and systematically present side effect descriptions. |
Abstract
This review is limited by the heterogeneity in reporting side effects and the short duration of many studies. Future studies should transparently and systematically present a description of side effects.
Comparable studies
Other narrative reviews on LSD and microdosing, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The risk of chronic psychedelic and MDMA microdosing for valvular heart disease | 2023 | Review | |
| Macrodosing to microdosing with psychedelics: Clinical, social, and cultural perspectives | 2022 | Review | |
| Is microdosing a placebo? A rapid review of low-dose LSD and psilocybin research | 2024 | Rapid review | n = 19 |
| Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia. | 2025 | Review | |
| Self-medication with psychedelics: a scoping review and narrative synthesis of review-level evidence Self-medicating individuals | 2026 | Scoping review |