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Mindfulness-based cognitive therapy in COPD: a cluster randomised controlled trial.

Ingeborg Farver-Vestergaard, Mia S O'Toole, Maja O'Connor, Anders Løkke, Elisabeth M. Bendstrup, Sharee A Basdeo, Donal J Cox, Pádraic J Dunne, Kai Ruggeri, Frances Early, Robert Zachariae

The European respiratory journal February 2018 DOI: 10.1183/13993003.02082-2017 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Cluster randomized controlled trial Peer reviewed
Sample size 84
Population Patients with chronic obstructive pulmonary disease (COPD) eligible for pulmonary rehabilitation
Interventions Mindfulness-based cognitive therapy (MBCT) pulmonary rehabilitation
Duration 8-week intervention; follow-up at 3 and 6 months
Measures Hospital Anxiety and Depression Scale (HADS), COPD Assessment Test (CAT)
Topics Meditation
Key findings MBCT added to standard pulmonary rehabilitation produced a statistically significant and durable improvement in psychological distress (HADS; Cohen's d=0.62, 95% CI 0.18-1.06, p=0.010) that persisted to 6 months. The effect on physical health status (CAT) did not reach statistical significance (d=0.42, 95% CI -0.06-0.90, p=0.061). The authors conclude that MBCT may be an efficacious add-on to standard PR in COPD.

Abstract

A considerable proportion of patients with chronic obstructive pulmonary disease (COPD) entering pulmonary rehabilitation (PR) report psychological distress, which is often accompanied by poor physical health status. Mindfulness-based cognitive therapy (MBCT) has been shown to improve psychological and physical outcomes in other chronic diseases. We therefore evaluated the efficacy of MBCT as an add-on to a standard PR programme in COPD.COPD patients eligible for PR were cluster randomised to receive either an 8-week, group-based MBCT programme as an add-on to an 8-week PR programme (n=39), or PR alone (n=45). The primary outcomes of psychological distress and physical health status impairment were measured with the Hospital Anxiety and Depression Scale (HADS) and the COPD Assessment Test (CAT) before randomisation (T1), mid- (T2) and post-intervention (T3), and at 3 (T4) and 6 (T5) months' follow-up .A statistically significant time×arm effect was found for the HADS (Cohen's d=0.62, 95% CIs (d)=0.18-1.06, p=0.010). The treatment effect on the CAT failed to reach statistical significance (d=0.42, 95% CIs (d)=-0.06-0.90, p=0.061).MBCT showed a statistically significant and durable effect on psychological distress, indicating that MBCT may be an efficacious add-on to standard PR programmes in COPD.

Comparable studies

Other randomized controlled trials on meditation, most cited first.

Study Year Design Participants
Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment 2003 Randomized controlled trial n = 41
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults 2008 Randomized controlled trial n = 139
Short-term meditation training improves attention and self-regulation Undergraduate Chinese students 2007 Randomized controlled trial n = 40
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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Meditation Anxiety Depression