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Randomized Trial of the Effect of Mindfulness-Based Stress Reduction on Pain-Related Disability, Pain Intensity, Health-Related Quality of Life, and A1C in Patients With Painful Diabetic Peripheral Neuropathy.

Howard J Nathan, Patricia A Poulin, Denise Wozny, Monica Taljaard, Cathy Smyth, Ian Gilron, Alexander Sorisky, Heather Lochnan, Yaad Shergill

Clinical diabetes : a publication of the American Diabetes Association December 2017 DOI: 10.2337/cd17-0077 (opens in new tab)

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Characteristics Randomized controlled trial Peer reviewed
Population Patients with painful diabetic peripheral neuropathy whose pharmacotherapy had been optimized in a chronic pain clinic
Intervention Mindfulness-based stress reduction (MBSR)
Topics Meditation
Key findings Patients with painful diabetic peripheral neuropathy randomized to community-based MBSR courses experienced improved function, better health-related quality of life, and reduced pain intensity, pain catastrophizing, and depression compared with those receiving usual care.

Abstract

IN BRIEF Painful diabetic peripheral neuropathy (PDPN) has a large negative impact on patients' physical and mental functioning, and pharmacological therapies rarely provide more than partial relief. Mindfulness-based stress reduction (MBSR) is a group psychosocial intervention that was developed for patients with chronic illness who were not responding to existing medical treatments. This study tested the effects of community-based MBSR courses for patients with PDPN. Among patients whose PDPN pharmacotherapy had been optimized in a chronic pain clinic, those randomly assigned to treatment with MBSR experienced improved function, better health-related quality of life, and reduced pain intensity, pain catastrophizing, and depression compared to those receiving usual care.

Comparable studies

Other randomized controlled trials on meditation, most cited first.

Study Year Design Participants
Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment 2003 Randomized controlled trial n = 41
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults 2008 Randomized controlled trial n = 139
Short-term meditation training improves attention and self-regulation Undergraduate Chinese students 2007 Randomized controlled trial n = 40
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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