A Receptor on Acid.
Qiuyan Chen, John J G Tesmer
Cell January 26, 2017 DOI: 10.1016/j.cell.2017.01.012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Structural biology study Peer reviewed |
|---|---|
| Intervention | LSD |
| Key points | Reports the crystal structure of LSD in complex with the 5-HT2B receptor, described as the first such structure for any psychedelic drug, and suggests it sheds light on molecular mechanisms underlying LSD's longer-lasting and more potent hallucinogenic effects compared with related compounds. |
Abstract
Wacker et al. report the crystal structure of LSD in complex with one of its major targets in the brain, the 5-HT2B receptor, the first such structure for any psychedelic drug. The results shed light on the molecular mechanisms underlying its ability to induce hallucinations with greater duration and potency than closely related compounds.
Citations in the library
Cited by 3
- 1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids? Frontiers in Psychiatry 2021
- Free energy calculations of the functional selectivity of 5-HT2B G protein-coupled receptor. PLoS One March 4, 2021
- Novel harmala-ocudelic tuning (HOT) for ocular disorders. Medical Hypotheses October 1, 2020
Cites 7
- Structural Features for Functional Selectivity at Serotonin Receptors Science March 21, 2013
- Crystal structure of an LSD-bound human serotonin receptor Cell January 26, 2017
- Serotonin, But Not N -Methyltryptamines, Activates the Serotonin 2A Receptor Via a β-Arrestin2/Src/Akt Signaling Complex In Vivo Journal of Neuroscience October 6, 2010
- Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans The International Journal of Neuropsychopharmacology June 24, 2015
- How LSD Originated Journal of Psychedelic Drugs 1979
and 2 more in the library