Psychological Status, Compliance, Serum Brain-Derived Neurotrophic Factor, and Nerve Growth Factor Levels of Patients with Depression after Augmented Mindfulness-Based Cognitive Therapy.
Huirong Guo, Yuming Ren, Bailing Huang, Junru Wang, Xuhuang Yang, Yali Wang
Genetics research 2022 DOI: 10.1155/2022/1097982 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 160 |
| Population | Patients with depression at The First Affiliated Hospital of Zhengzhou University |
| Interventions | Mindfulness-based cognitive therapy (MBCT) pharmacotherapy |
| Duration | 8 weeks |
| Measures | 17-item Hamilton Depression Rating Scale (HAMD-17), Rosenberg Self-esteem Scale (RSES), Self-Acceptance Questionnaire (SAQ), Stigma Scale (Scale of Stigma in People with Mental Illness, SSPM), enzyme-linked immunosorbent assay (ELISA) for BDNF and NGF |
| Topics | Depression Meditation |
| Key findings | Adding mindfulness-based cognitive therapy to standard pharmacotherapy for 8 weeks reduced depression severity, increased self-esteem and self-acceptance, lowered stigma, and raised serum BDNF and NGF levels compared with pharmacotherapy alone in patients with depression. |
Abstract
Mindfulness-based cognitive therapy (MBCT) is a cost-effective psychosocial program that prevents relapse/recurrence in major depression. The present study aimed to analyze the effects of augmented MBCT along with standard treatment dominated by pharmacotherapy on psychological state, compliance, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) expression levels in patients with depression. A total of 160 eligible patients with depression in The First Affiliated Hospital of Zhengzhou University were included in this study. The study randomly assigned the patients to the experimental group (n = 80) and control group (n = 80). All participants were assessed with the questionnaires including the 17-item Hamilton Depression Rating Scale (HAMD-17), Rosenberg Self-esteem Scale (RSES), Self-Acceptance Questionnaire (SAQ), and Stigma Scale (Scale of Stigma in People with Mental Illness, SSPM). The serum levels of BDNF and NGF were detected by enzyme-linked immunosorbent assay (ELISA). After 8 weeks of treatment, the experimental group showed significant lower HAMD-17 score, higher RSES, and SAQ score, as well as lower SSPM score compared with the control group (P < 0.01). Furthermore, ELISA revealed that the serum levels of BDNF and NGF remarkably increased in the experimental group after treatment (P < 0.001). Our data showed that augmented MBCT combined with pharmacotherapy contributed to improvement on patients' psychological state, compliance, and disease recurrence.
Comparable studies
Other randomized controlled trials on depression, most cited first.
Citations in the library
Cited by 4
- A randomized controlled trial of mindfulness-based cognitive therapy for major depressive disorder in undergraduate students: Dose- response effect, inflammatory markers and BDNF. Psychiatry Research 2024
- The correlation between cumulative burden of mental disorders and self-harm, shame, and insight in young female patients with schizophrenia. European Archives of Psychiatry and Clinical Neuroscience April 1, 2025
- Serum BDNF Increase After 9-Month Contemplative Mental Training Is Associated With Decreased Cortisol Secretion and Increased Dentate Gyrus Volume: Evidence From a Randomized Clinical Trial. Biological Psychiatry Global Open Science March 1, 2025
- Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial. Frontiers in Psychiatry 2023
Cites 6
- Meditation Programs for Psychological Stress and Well-being JAMA Internal Medicine January 6, 2014
- Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Journal of Consulting and Clinical Psychology 2004
- Mindfulness-Based Cognitive Therapy: Theory and Practice The Canadian Journal of Psychiatry February 1, 2012
- Outcomes of Online Mindfulness-Based Cognitive Therapy for Patients With Residual Depressive Symptoms: A Randomized Clinical Trial. JAMA Psychiatry January 29, 2020
- Mindfulness‐based cognitive therapy for patients with chronic, treatment‐resistant depression: A pragmatic randomized controlled trial Depression and Anxiety August 8, 2018
and 1 more in the library