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Positive Affect as a Transdiagnostic Target for Reducing Adolescent Depression & Suicide Risk: Do Mindfulness, Savoring, & Gratitude Help?

Natalia Macrynikola, Jackson Doerr, Shirley Yen

Journal des adolescens June 3, 2026 DOI: 10.1002/jad.70189 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Pilot randomized controlled trial Peer reviewed
Sample size 52
Population Adolescents ages 12-18 hospitalized for suicide-related reasons in the northeastern U.S. (62% female, 31% male, 8% transgender)
Intervention savoring
Topics Depression Meditation
Key findings Increases in positive affect predicted lower depressive symptoms (B = 1.00) and lower suicide ideation (B = 3.04) at follow-up. Mindfulness and savoring increases predicted lower depressive symptoms and, for savoring, lower suicide ideation; gratitude was only marginally associated with depressive symptoms and not with suicide ideation. The authors argue positive affect is a transdiagnostic target for adolescent depression and suicide risk.

Abstract

Introduction: Despite its known contribution to adolescent depression and suicide risk, low positive affect (PA) remains underemphasized in clinical interventions, with limited evidence on how to best enhance it. Using data from a pilot randomized controlled trial of a brief PA-enhancing intervention for high-risk youth, we hypothesized that increases in PA over the intervention period would prospectively predict lower depressive symptoms and suicide ideation (SI). We also hypothesized that increases in mindfulness, savoring, and gratitude would prospectively predict higher PA and lower depressive symptoms and SI.

Methods: Participants were 52 adolescents, ages 12-18 (62% female, 31% male, 8% transgender) hospitalized for suicide-related reasons in the northeastern U.S.

Results: PA increases (using an anhedonia measure, where lower scores reflect greater PA) predicted lower T2 depressive symptoms, B = 1.00, p < 0.01, and lower T2 SI, B = 3.04, p < 0.01. Mindfulness increases predicted lower T2 depressive symptoms, B = -14.55, p < 0.01, and were marginally associated with lower T2 SI, B = -23.93, p = 0.08. Savoring increases predicted lower T2 depressive symptoms, B = -3.68, p < 0.05, and lower T2 SI, B = -17.50, p < 0.01. Gratitude increases were marginally associated with T2 depressive symptoms, B = -0.68, p = 0.07, but not T2 SI. Mindfulness, savoring, and gratitude increases were significant predictors of higher T2 PA. All analyses adjusted for T1 scores.

Conclusion: Findings support PA as a transdiagnostic target for adolescent depression and suicide risk. When developmentally tailored, mindfulness, savoring, and gratitude strategies may help enhance PA. Larger studies are needed to confirm these preliminary findings.

Comparable studies

Other randomized controlled trials on depression, most cited first.

Study Year Design Participants
A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Subjects with DSM-IV major depression (treatment resistant) 2006 Randomized, placebo-controlled, double-blind crossover study n = 18
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients 2004 Randomized controlled trial n = 73

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