Serotoninergic agents in the treatment of isolated sleep paralysis.
S Snyder, G Hams
American Journal of Psychiatry September 1982 DOI: 10.1176/ajp.139.9.1202 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 3 |
| Population | Individuals with isolated sleep paralysis |
| Interventions | L-tryptophan amitriptyline imipramine |
| Topics | Serotonin |
| Key findings | In three reported cases, isolated sleep paralysis was controlled by L-tryptophan, given with or without amitriptyline. The authors suggest this may relate to increased central 5-hydroxytryptamine availability, noting that imipramine, which acts mainly on norepinephrine reuptake, was ineffective in the one case in which it was tried. |
Abstract
The authors report three cases of isolated sleep paralysis controlled by L-tryptophan with or without amitriptyline. Both agents increase CNS 5-hydroxytryptamine availability, whereas imipramine, which was ineffective in the one case in which it was tried, affects predominantly norepinephrine reuptake.
Comparable studies
Other case reports and case series on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users Persons who ingested large doses of MDMA | 1991 | Case study | n = 2 |
| Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user Chronic MDMA user | 2000 | Case study | n = 1 |
| Death following ingestion of MDMA (ecstasy) and moclobemide People who died after ingesting moclobemide and MDMA | 2003 | Case series | n = 4 |
| Ecstasy Intoxication: An Overlap Between Serotonin Syndrome and Neuroleptic Malignant Syndrome A 19-year-old woman and 15 other cases reported in the literature | 1996 | Case report and literature review | n = 16 |
| Recurrent seizures and serotonin syndrome following "2C-I" ingestion. 19-year-old male who insufflated 2C-I | 2013 | Case report | n = 1 |