Recurrent seizures and serotonin syndrome following "2C-I" ingestion.
Adam Bosak, Frank Lovecchio, Michael Levine
Journal of medical toxicology : official journal of the American College of Medical Toxicology June 1, 2013 DOI: 10.1007/s13181-013-0287-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 19-year-old male who insufflated 2C-I |
| Topics | Serotonin |
| Keywords | 2c-i toxicity 2c-i poisoning 2c-i adverse effects 2c-i overdose 2c-i reactions Designer drugs Synthetic drugs Novel psychoactive substances Emerging drugs Medical emergency Acute drug intoxication Drug-induced crisis Critical care Emergency medicine Patient recovery Full recovery Positive patient outcome Clinical recovery |
| Citations | 59 |
| Key findings | Insufflation of 2C-I can cause recurrent seizures, serotonin syndrome, and prolonged respiratory failure, with the possibility of full recovery. |
Abstract
The phenethylamines, including 2, 5 dimethoxy-4-iodophenethylamine, commonly referred to as 2C-I, have recently emerged as a new class of designer drugs. Cases of toxicity from these drugs are not well described in the literature. This case report describes a 19 year-old male who insufflated 2C-I. Following the ingestion, the patient developed recurrent seizures, and was taken to the emergency department, where he was noted to be hyperadrenergic and had recurrent seizures. The patient was diagnosed with serotonin syndrome and experienced prolonged respiratory failure, although he ultimately made a full recovery. Comprehensive drug testing revealed the presence of 2C-I. The pharmacologic properties of 2C-I are also discussed.