9 -tetrahydrocannabinol: dose-related effects on timing behavior in chimpanzee.
D G Conrad, T F Elsmore, F J Sodetz
Science (New York, N.Y.) February 4, 1972 DOI: 10.1126/science.175.4021.547 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Population | Chimpanzees with stable, efficient timing performances maintained by multilink chained schedules of food reinforcement |
| Intervention | Delta(9)-Tetrahydrocannabinol |
| Dose | doses within the effective range for humans |
| Duration | Effects up to 3 days at higher doses |
| Topics | Cannabis |
| Key points | Oral delta(9)-tetrahydrocannabinol reduced food reinforcements in chimpanzees performing timing tasks, due to both fewer total operant timing responses and decreased accuracy of the timing responses that occurred. Higher doses produced effects lasting up to 3 days. |
Abstract
Delta(9)-Tetrahydrocannabinol, at doses within the effective range for humans, was administered orally to chimpanzees with stable, efficient timing performances maintained by multilink chained schedules of food reinforcement. Reinforcements decreased with increasing dose, because of decreased frequencies of total operant timing responses and decreased accuracy of the timing performances which did occur. Higher doses exerted an effect for up to 3 days.