Comparison of tetrahydrocannabinol and synhexyl in man
Leo E. Hollister, R. K. Richards, H. K. Gillespie
Clinical Pharmacology & Therapeutics November 1, 1968 DOI: 10.1002/cpt196896783 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 16 |
| Population | Volunteer subjects |
| Interventions | THC synhexyl |
| Dose | THC: 341 to 946 µg/kg (median 581); synhexyl: 633 to 2,666 µg/kg (median 1,370) |
| Topics | Cannabis |
| Keywords | Euphoriant Volunteer Sedation Dronabinol Pharmacology Toxicology |
| Citations | 195 |
| Key findings | Synhexyl produced clinical effects similar to THC but was slower in onset and about one third as potent, with effects at higher doses resembling LSD but with more sedation, longer euphoria, and no sympathomimetic effects. |
Abstract
A synthetic isomer of tetrahydrocannabinol (1‐Δ'‐3,4‐transtetrahydrocannabinol), believed to be identical to the most active naturally occurring THC, was compared with a semisynthetic THC‐like compound, synhexyl. Sixteen volunteer subiects received THC in doses ranging from 341 to 946 p.g per kilo gram (median 581). Thirteen subjects received synhexyl in doses ranging from 633 to 2,666 µg per kilogram (median 1,370). Clinical syndromes tram the 2 drugs were similar, although synhexyl was slower in onset and only about one third as potent. The clinical effects resembled those of psychotomimetics such as LSD, at least at the higher doses. These drugs differed from LSD in the following respects: sedation was prominent; euphoria was langer lasting; dreamlike sequences more pronounced; and physiological and biochemical effects were somewhat different, especially in the absence of sympathomimetic effects.