Clinical, Cognitive, and Neurobiological Correlates of Impaired Timing Abilities Associate to Cannabis Use: a Systematic Review
Andrea Escelsior, Alice Trabucco, M. Radicati, M. Murri, Beatriz Pereira da Silva, Gianluca Serafini, Mario Amore
International Journal of Mental Health and Addiction August 29, 2023 DOI: 10.1007/s11469-023-01125-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Topics | Cannabis |
| Key findings | Cannabis use impairs time estimation and reproduction abilities and causes subjective temporal fragmentation and depersonalization, likely via dopaminergic action and alterations in the cerebello-thalamo-cortical circuit. |
Abstract
Time perception received growing interest in psychiatry for its psychopathological implications. Cannabis use can cause a subjective experience of temporal perception alteration and increases the risk of emergence of mental illnesses such as psychotic and mood disorders. In this framework, we systematically reviewed the findings regarding the clinical, cognitive, and neurobiological correlates of time alterations due to cannabis consumption. According to preclinical results, cannabis exerts a dose-dependent time overestimation, associated with motor inhibition and circadian alterations. Clinical results reported that cannabis impair time estimation and time reproduction abilities, causing subjective temporal fragmentation and depersonalization symptoms. The alteration of timing mediated by cannabis use might depend on a dopaminergic indirect action and on structural, functional, and metabolic alterations of the cerebello-thalamo-cortical circuit. Despite the potential interest, however, only few studies explored the link between cannabis-induced alterations of time processing and psychiatric symptoms.