Screening hallucinogenic drugs II. Systematic study of two behavioral tests.
H M Calil
Psychopharmacology January 31, 1978 DOI: 10.1007/bf00571414 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Key points | The modified Bovet-Gatti profile method produced its "hallucinogenic profile" with both hallucinogenic and nonhallucinogenic drugs and was therefore not suitable as a screening method in this use. The authors suggest that drug discrimination may hold potential value for drug screening procedures. |
Abstract
The effects of hallucinogenic and nonhallucinogenic drugs were studied on two behavioral tests: (1) discriminated Sidman avoidance, using modified Bovet-Gatti profiles, which have been proposed as specific in detecting hallucinogenic activity and (2) a drug discrimination experiment. By the first method, the "hallucinogenic profile" was obtained with both hallucinogenic and nonhallucinogenic drugs and, at least as used here, was not a suitable screening method. In the drug discrimination experiment, data from the present study along with other available evidence suggest the potential value of this method for drug screening procedures.
Citations in the library
Cited by 4
- Acute but not long-lasting antidepressant-like effect of psilocybin in differential reinforcement of low-rate 72 schedule in rats Journal of Psychopharmacology October 16, 2023
- Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics. ACS Chemical Neuroscience November 5, 2025
- Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines. Psychopharmacology April 2009
- Comparison of stimulants and hallucinogens on shuttle avoidance in rats. General pharmacology 1987
Cites 3
- Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli Psychopharmacology 1971
- Comparison of the discriminative stimulus properties of Δ9-THC and psilocybin in rats Pharmacology, Biochemistry, and Behavior September 1, 1975
- Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs. Psychopharmacologia April 15, 1976