Delta 9-Tetrahydrocannabinol, ethanol, and amphetamine as discriminative stimuli-generalization tests with other drugs.
O F Bueno, E A Carlini, E Finkelfarb, J S Suzuki
Psychopharmacologia April 15, 1976 DOI: 10.1007/bf00421108 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal drug-discrimination experiment Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | delta 9-THC ethanol amphetamine delta 8-THC CBD CBN pentobarbital chlorpromazine apomorphine |
| Dose | delta 9-THC 5.0 mg/kg; ethanol 1.2 g/kg; amphetamine 1.0 mg/kg |
| Topics | Cannabis |
| Key findings | Rats trained to discriminate delta 9-THC, ethanol, or amphetamine cues generalized selectively: delta 8-THC and CBN substituted for delta 9-THC, pentobarbital substituted for ethanol, and delta 9-THC and apomorphine substituted for amphetamine. Other tested drugs, including CBD, did not produce these drug-like responses. |
Abstract
Three groups of rats (A, B, C) were trained in a T-maze discriminate between drug-and control solution-induced internal discriminative stimuli. The drugs used to induce discriminative stimuli were: delta 9-THC, 5.0 mg/kg (Group A); ethanol, 1.2 g/kg (Group B), and amphetamine, 1.0 mg/kg(Group C). After discrimination acquisition several drugs were tested for generalization in each group. Group A was tested with delta 8-THC, CBD, CBN, ethanol, pentobarbital,chlorpromazine, amphetamine, and apomorphine; only delta8-THC and CBN induced delta9-THC-like responses. Group B was tested with delta 9-THC, delta 8-THC, CBD, CBN, pentobarbital, and amphetamine; pentobarbital induced ethanol-like response. Group C was tested with delta 9-THC, apomorphine, and ethanol; delta 9-THC and apomorphine elicited amphetamine-like responses.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cited by 7
- Evaluation of cannabimimetic effects of selected minor cannabinoids and Terpenoids in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry June 8, 2024
- Human Drug Discrimination: Elucidating the Neuropharmacology of Commonly Abused Illicit Drugs. Current Topics in Behavioral Neurosciences 2018
- Substitution profile of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in humans discriminating Delta9-tetrahydrocannabinol. Psychopharmacology April 2009
- Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by delta 9-THC in the rat. Psychopharmacology 1992
- The role of benzodiazepine receptors in the discriminative stimulus properties of delta-9-tetrahydrocannabinol. Life Sciences April 28, 1986
and 2 more in the library