Comparison of the discriminative stimulus properties of Δ9-THC and psilocybin in rats
Isaac Greenberg, D. M. Kuhn, James B. Appel
Pharmacology, Biochemistry, and Behavior September 1, 1975 DOI: 10.1016/0091-3057(75)90131-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Male albino rats |
| Interventions | delta9-THC psilocybin |
| Dose | 1.9 mg/kg of delta9-THC; 1.0 mg/kg of delta9-THC; 1.0 mg/kg of psilocybin |
| Duration | 30 min before experimentation |
| Topics | Psilocybin Cannabis |
| Keywords | Stimulus control Lever Discriminative model Stimulus psychology Pharmacology Hallucinogen Cognitive psychology Artificial intelligence |
| Citations | 17 |
| Key findings | Delta9-THC and psilocybin produce discriminably different internal states in rats, as shown by differential lever choice. |
Abstract
Male albino rats were trained to respond differentially on the left or right lever in a 2-lever chamber on the basis of which drug had been given intra-peritoneally (IP) 30 min before experimentation. In 1 group 1.9 mg/kg of delta9-THC and control injections (vehicle) served as the discriminative stimuli associated with each lever and in another group the drug stimuli were 1.0 mg/kg of delta9-THC and 1.0 mg/kg of psilocybin. The results confirmed those of other experiments using different procedures; that delta9-THC can acquire discriminative control over responding. The fact that delta9-THC and psilocybin were also found to differentially control lever choice demonstrates that these 2 drugs probably produce discriminably different states in rats.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.
Citations in the library
Cited by 7
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- Psilocybin as a discriminative stimulus: Lack of specificity in an animal behavior model for ?hallucinogens? Psychopharmacology February 1, 1982
- Utility of preclinical models in the study of psilocybin – A comprehensive review Neuroscience & Biobehavioral Reviews January 13, 2023
- Early preclinical studies of discriminable sedative and hallucinogenic drug effects. Psychopharmacology April 2009
- Delta 9-tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neuroscience and biobehavioral reviews 1992
and 2 more in the library