Stereoselective effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) on schedule-controlled behavior.
R A Harris, D Snell, H H Loh
Pharmacology, Biochemistry, and Behavior October 1977 DOI: 10.1016/0091-3057(77)90225-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | R S-DOM |
| Key findings | R(-)-, S(+), and R,S-DOM all decreased average rates of fixed-interval responding in rats in a dose-related manner, with R-DOM five to six times more potent than S-DOM. The drugs also produced rate-dependent effects, raising low early-interval response rates and lowering higher late-interval rates. |
Abstract
The effects of R(-)-, S(+) and R, S-1-2-5-dimethoxy-4-methylphenyl)-2-Aminopropane (DOM) were studied using rats responding under a fixed interval two-min schedule of food presentation. All three drugs decreased average rates of responding in a dose-related manner, with R -DOM being five to six times more potent than S-DOM increased the low response rates occurring at the beginning of the fixed interval and decreased the higher response rates occurring at the end of the interval (rate-dependent effects). These results are discussed in terms of the stereoselective metabolism of DOM and of the structural similarities between R-DOM and the behaviorally active isomer of LSD.
Citations in the library
Cited by 3
- Differential phospholipase C activation by phenylalkylamine serotonin 5‐HT2Areceptor agonists Journal of Neurochemistry November 8, 2005
- Self-injection of d,1-3,4-methylenedioxymethamphetamine (MDMA) in the baboon. Psychopharmacology 1987
- The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM): differentiation from amphetamine. Psychopharmacology 1980