5-Methoxy-NN-dimethyltryptamine: differential modulation of the rewarding and aversive components of lateral hypothalamic self-stimulation.
J D Sinden, D M Atrens
Journal of Pharmacy and Pharmacology April 1, 1978 DOI: 10.1111/j.2042-7158.1978.tb13226.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-Methoxy-N N-dimethyltryptamine |
| Topics | Serotonin 5-MeO-DMT DMT |
| Keywords | Hypothalamus Animals Rats Bufotenin Hallucinogens Escape reaction Self stimulation Reward Male |
| Key points | Argues that 5-methoxy-N,N-dimethyltryptamine differentially modulates the rewarding and aversive components of lateral hypothalamic self-stimulation in rats, suggesting separate serotonergic influences on these two aspects of brain stimulation reward. |
Abstract
J D Sinden, D M Atrens; 5-Methoxy-NN-dimethyltryptamine: differential modulation of the rewarding and aversive components of lateral hypothalamic self-stimulati
Comparable studies
Other preclinical and animal studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. Human primary monocyte-derived dendritic cells | 2014 | In vitro study | |
| Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression Adult male Sprague-Dawley rats | 2018 | Experimental study | |
| Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Mice and rats | 2006 | Preclinical study | |
| Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors Rats and transfected fibroblasts | 1998 | Experimental study | |
| Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat Intact rats and rats depleted of monoamines with reserpine | 1985 | Experimental study |