Inhibition of phrenic and sympathetic vasomotor neurons in cats by the serotonin analog 5-methoxy-N,N-dimethyltryptamine.
P. Lalley
Journal of Pharmacology and Experimental Therapeutics March 1, 1982 DOI: 10.1016/s0022-3565(25)32894-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal physiology experiment Peer reviewed |
|---|---|
| Interventions | 5-Methoxy-N Cinanserin |
| Dose | 5MeODMT 20-200 microgram/kg; cinanserin 2-4 mg/kg; high-dose 5MeODMT 200-700 microgram/kg i.v. |
| Topics | 5-MeO-DMT DMT Serotonin |
| Key findings | 5MeODMT (20-200 micrograms/kg) rapidly inhibited phrenic and sympathetic nerve discharges and depressed blood pressure, with recovery after about 20 minutes. Phrenic inhibition was prevented by hypercapnia and hyperthermia, reversed by 50 Hz carotid sinus nerve stimulation, and antagonized by cinanserin; sympathetic inhibition was reversed by carotid sinus stimulation but unaffected by hypercapnia, hyperthermia, or cinanserin. The authors attribute these effects to direct agonist action on central serotonin receptors and propose that different serotonin receptor types mediate the two inhibitions. |
Abstract
5-Methoxy-N,N-dimethyltryptamine (20-200 microgram/kg) inhibits phrenic and sympathetic neural discharges and depresses blood pressure. The effects occur within seconds after injection. Complete recovery occurs, on the average, after 20 min. The inhibition of phrenic nerve discharges is prevented during hypercapnia and hyperthermia and reversed during 50 Hz electrical stimulation of the carotid sinus nerve. Cinanserin (2-4 mg/kg) antagonize the inhibition of phrenic nerve activity. Inhibition of sympathetic activity by 5MeODMT is also reversed during 50 Hz carotid sinus nerve stimulation, but is unaltered by hypercapnia, hyperthermia or cinanserin. High doses of 5MeODMT (200-700 microgram/kg i.v.) produce an initial apneustic discharge which is followed by inhibition of phrenic discharges. The inhibitory effects of 5MeODMT are attributed to a direct agonist action on central nervous serotonin receptors. The inhibition of phrenic and sympathetic neurons appears to be mediated by different types of serotonin receptors.
Comparable studies
Other experimental studies on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Human cerebral organoids | 2017 | Experimental study | |
| Bufo alvarius: a potent hallucinogen of animal origin. Bufo alvarius toad venom | 1994 | Experimental study | |
| Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment Volunteers | 2019 | Within-subjects experimental study | n = 11 |
| Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Adult cats | 1990 | Experimental study | n = 10 |
| Studies on the Mechanism of Action of Monoamine Oxidase: Metabolism of N,N-Dimethyltryptamine and N,N-Dimethyltryptamine-N-Oxide | 1962 | Experimental study |
Citations in the library
Cited by 3
- Unmasking of a neonatal somatovesical reflex in adult cats by the serotonin autoreceptor agonist 5-methoxy-N,N-dimethyltryptamine. Brain research. Developmental brain research June 1, 1990
- The excitability and rhythm of medullary respiratory neurons in the cat are altered by the serotonin receptor agonist 5-methoxy-N,N, dimethyltryptamine. Brain Research June 13, 1994
- The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner Journal of Psychopharmacology February 12, 2020