Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor.
R. Grailhe, C. Waeber, S. Dulawa, J. Hornung, X. Zhuang, D. Brunner, Mark A. Geyer, R. Hen
Neuron March 1, 1999 DOI: 10.1016/s0896-6273(00)80712-6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study (genetic knockout model) Peer reviewed |
|---|---|
| Population | Wild-type and 5-HT5A knockout mice |
| Intervention | LSD |
| Measures | exploratory activity, anxiety-related behaviors |
| Topics | LSD Serotonin |
| Key findings | Knockout mice lacking the 5-HT5A receptor showed increased exploratory activity in novel environments but no change in anxiety-related behaviors, and the stimulatory effect of LSD on exploratory activity was attenuated. This suggests that 5-HT5A receptors modulate exploratory behavior and may mediate some psychotropic effects of LSD. |
Abstract
In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bulb, neocortex, and medial habenula. When exposed to novel environments, the 5A-KO mice displayed increased exploratory activity but no change in anxiety-related behaviors. In addition, the stimulatory effect of LSD on exploratory activity was attenuated in 5A-KO mice. These results suggest that 5-HT5A receptors modulate the activity of neural circuits involved specifically in exploratory behavior and suggest that some of the psychotropic effects of LSD may be mediated by 5-HT5A receptors.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
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