Molecular targets of psychedelic‐induced plasticity
Alaina M Jaster, Mario de la Fuente Revenga, Javier González-Maeso
Journal of Neurochemistry November 6, 2021 DOI: 10.1111/jnc.15536 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Neuroplasticity |
| Keywords | Cognitive psychology |
| Citations | 28 |
| Key findings | The review identifies knowledge gaps and limitations in evaluating the potential antidepressant action of psychedelics, emphasizing the role of the serotonin 5-HT2A receptor and synaptic plasticity. |
Abstract
Abstract Psychedelic research across different disciplines and biological levels is growing at a remarkably fast pace. In the prospect of a psychedelic drug becoming again an approved treatment, much of these efforts have been oriented toward exploring the relationship between the actual psychedelic effects and those manifestations of therapeutic interest. Considering the central role of the serotonin 5‐HT 2A receptor in the distinct effects of psychedelics in human psyche, neuropharmacology sits at the center of this debate and exploratory continuum. Here we discuss some of the most recent findings in human studies and contextualize them considering previous preclinical models studying phenomena related to synaptic plasticity. A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings of psychedelics’ potential antidepressant action. image