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Self-Guided Internet-Based Mindfulness-Informed Stress Management for Generalized Anxiety Disorder: Randomized Controlled Trial With Longitudinal Network Analysis.

Journal of Medical Internet Research June 5, 2026 DOI: 10.2196/91751 (opens in new tab)

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AI-extracted from the abstract
Characteristics Randomized controlled trial Longitudinal Peer reviewed
Intervention Self-guided internet-based mindfulness-informed stress management
Topics Anxiety Meditation
Key findings The self-guided internet-based mindfulness-informed stress management program reduced anxiety symptoms in adults with generalized anxiety disorder compared to a control condition. Longitudinal network analysis indicated shifts in symptom connectivity, suggesting the intervention may alter how anxiety symptoms interact. The authors propose that such digital interventions could be a viable treatment option, though they call for more research.

Abstract

Self-Guided Internet-Based Mindfulness-Informed Stress Management for Generalized Anxiety Disorder: Randomized Controlled Trial With Longitudinal Network Analysis.

Comparable studies

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Study Year Design Participants
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients 2000 Randomized controlled trial n = 145
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety 2016 Randomized controlled trial n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression 2016 Double-blind, placebo-controlled, crossover trial n = 29
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Hallucinogen-naïve adults reporting regular participation in religious or spiritual... 2006 Double-blind study n = 36
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Adults with advanced-stage cancer and anxiety 2010 Double-blind, placebo-controlled study n = 12

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