Fatal Intoxications with 25B-NBOMe and 25I-NBOMe in Indiana During 2014.
Kevin G Shanks, Thomas J. Sozio, George S Behonick
Journal of Analytical Toxicology October 1, 2015 DOI: 10.1093/jat/bkv058 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case series Case report Peer reviewed |
|---|---|
| Sample size | 2 |
| Population | Two teenage male subjects who died in Indiana in 2014 |
| Key findings | Two deaths were attributed to NBOMe substances: 25B-NBOMe was detected in postmortem heart blood at 1.59 ng/mL in one case, and 25I-NBOMe at 19.8 ng/mL in the other. The authors review published cases confirming these substances as causative agents in intoxications and deaths. |
Abstract
Over the last few years, NBOMe substances have been used either as a legal alternative to lysergic acid diethylamide (LSD) or sold surreptitiously as LSD to unknown users. These NBOMe substances have been detected in blotter papers, powders, capsules and liquids. We report the deaths of two teenage male subjects that were related to 25B-NBOMe and 25I-NBOMe in Indiana during 2014. Samples were extracted via a solvent protein precipitation with acetonitrile and analyzed via ultra-performance liquid chromatography with tandem mass spectrometry. For these two cases, we describe the NBOMe instrumental analysis, toxicological results for postmortem heart blood and urine specimens and the relevant case history and pathological findings at autopsy. In the first case, 25B-NBOMe was detected in postmortem heart blood at 1.59 ng/mL; in the second case, 25I-NBOMe was detected in postmortem heart blood at 19.8 ng/mL. We also review relevant published casework from clinical toxicology and postmortem toxicology in which analytically confirmed 25B-NBOMe and 25I-NBOMe were determined to be causative agents in intoxications or deaths.
Citations in the library
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- Designer drugs: mechanism of action and adverse effects Archives of Toxicology April 1, 2020
- Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens. Current Topics in Behavioral Neurosciences 2017
- NBOMes–Highly Potent and Toxic Alternatives of LSD Frontiers in Neuroscience February 26, 2020
- DARK Classics in Chemical Neuroscience: NBOMes ACS Chemical Neuroscience October 28, 2019
- Hallucinogen-Like Action of the Novel Designer Drug 25I-NBOMe and Its Effect on Cortical Neurotransmitters in Rats Neurotoxicity Research April 15, 2019
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Cites 7
- 25C-NBOMe--new potent hallucinogenic substance identified on the drug market. Forensic Science International April 10, 2013
- Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe Clinical Toxicology 2014
- 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): clinical case with unique confirmatory testing. Journal of Medical Toxicology March 1, 2014
- Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Testing and Analysis August 1, 2013
- Evolution of the NBOMes: 25C- and 25B- Sold as 25I-NBOMe Journal of Medical Toxicology November 12, 2014
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