25C-NBOMe--new potent hallucinogenic substance identified on the drug market.
Dariusz Zuba, Karolina Sekuła, Agnieszka Buczek
Forensic Science International April 10, 2013 DOI: 10.1016/j.forsciint.2012.08.027 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Analytical chemistry study Peer reviewed |
|---|---|
| Population | Blotter papers seized from the drug market |
| Keywords | Drug identification Substance identification Chemical identification Drug analysis Compound identification Illicit drug Emerging compound Analytical chemistry Chemical analysis Spectroscopy Molecular analysis Chemical characterization Analytical techniques Emerging drugs Designer drugs Synthetic drugs New psychoactive substances Forensic chemistry Forensic analysis Drug forensics Crime lab analysis |
| Citations | 128 |
| Key points | The seized blotter papers contained the hallucinogenic substance 25C-NBOMe, identified through a comprehensive analytical approach including GC-MS, LC-QTOF-MS, FTIR, and NMR. |
Abstract
This publication reports analytical properties of a new hallucinogenic substance identified in blotter papers seized from the drug market, namely 25C-NBOMe [2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine]. The identification was based on results of comprehensive study including several analytical methods, i.e., GC-EI-MS (without derivatization and after derivatization with TFAA), LC-ESI-QTOF-MS, FTIR and NMR. The GC-MS spectrum of 25C-NBOMe was similar to those obtained for other representatives of the 25-NBOMe series, with dominant ions observed at m/z=150, 121 and 91. Fragment ions analogic to those in 2C-C (4-chloro-2,5-dimethoxy-β-phenylethanamine) were also observed, but their intensities were low. Derivatization allowed the determination of molecular mass of the investigated substance. The exact molecular mass and chemical formula were confirmed by LC-QTOF-MS experiments and fragmentation pattern under electrospray ionization was determined. The MS/MS experiments confirmed that the investigated substance was N-(2-methoxy)benzyl derivative of 2C-C. The substance was also characterized by FTIR spectroscopy to corroborate its identity. Final elucidation of the structure was performed by NMR spectroscopy.