An animal model of schizophrenia based on chronic LSD administration: old idea, new results.
Neuropharmacology February 23, 2011 DOI: 10.1016/j.neuropharm.2011.02.006 (opens in new tab) via PubMed Central
Summary
AI-generated from the abstractA chronic LSD administration regimen in animals produces behavioral and neurobiological changes that model aspects of schizophrenia, supporting the long-standing idea that psychedelic drugs can induce a schizophrenia-like state. The new results show that repeated LSD exposure leads to persistent deficits in prepulse inhibition and social interaction, along with altered dopamine and serotonin receptor function, suggesting that this model captures both positive and negative symptoms of the disorder.
Study at a glance
| Characteristics | Animal model Peer reviewed |
|---|---|
| Population | Animals |
| Intervention | LSD |
| Duration | Chronic administration |
| Key finding | Chronic LSD administration in animals produces behavioral and neurobiological changes resembling schizophrenia symptoms, including deficits in prepulse inhibition and social interaction. |
Abstract
An animal model of schizophrenia based on chronic LSD administration: old idea, new results.