Effects of LSD on grooming behavior in serotonin transporter heterozygous (Sert⁺/⁻) mice.
Evan J. Kyzar, Adam Michael Stewart, Allan V. Kalueff
Behavioural Brain Research 2016 DOI: 10.1016/j.bbr.2015.08.018 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Heterozygous Sert(+/-) and wild-type Sert(+/+) mice |
| Intervention | Lysergic acid diethylamide |
| Dose | 0.32 mg/kg |
| Topics | LSD Serotonin |
| Keywords | Grooming Hallucinogens Serotonin transporter |
| Key findings | Sert(+/-) mice displayed longer self-grooming regardless of LSD treatment, and LSD increased serotonin-sensitive behaviors similarly in both genotypes. |
Abstract
Serotonin (5-HT) plays a crucial role in the brain, modulating mood, cognition and reward. The serotonin transporter (SERT) is responsible for the reuptake of 5-HT from the synaptic cleft and regulates serotonin signaling in the brain. In humans, SERT genetic variance is linked to the pathogenesis of various psychiatric disorders, including anxiety, autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD). Rodent self-grooming is a complex, evolutionarily conserved patterned behavior relevant to stress, ASD and OCD. Genetic ablation of mouse Sert causes various behavioral deficits, including increased anxiety and grooming behavior. The hallucinogenic drug lysergic acid diethylamide (LSD) is a potent serotonergic agonist known to modulate human and animal behavior. Here, we examined heterozygous Sert(+/-) mouse behavior following acute administration of LSD (0.32 mg/kg). Overall, Sert(+/-) mice displayed a longer duration of self-grooming behavior regardless of LSD treatment. In contrast, LSD increased serotonin-sensitive behaviors, such as head twitching, tremors and backwards gait behaviors in both Sert(+/+) and Sert(+/-) mice. There were no significant interactions between LSD treatment and Sert gene dosage in any of the behavioral domains measured. These results suggest that Sert(+/-) mice may respond to the behavioral effects of LSD in a similar manner to wild-type mice.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 19
- Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms Pharmacological Reviews December 16, 2020
- d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology International Journal of Molecular Sciences November 23, 2016
- LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1 Scientific Reports September 5, 2021
- Exploring Hallucinogen Pharmacology and Psychedelic Medicine with Zebrafish Models Zebrafish March 22, 2016
- Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey. Scientific Reports August 17, 2023
and 14 more in the library
Cites 7
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Effects of Schedule I drug laws on neuroscience research and treatment innovation. Nature reviews. Neuroscience June 12, 2013
- Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. Neuropharmacology January 20, 2011
- The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nature Reviews Neuroscience September 2010
- Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition. Progress in Neuro-Psychopharmacology and Biological Psychiatry May 30, 2010
and 2 more in the library