The Effects of Mindfulness on Brain Network Dynamics Following an Acute Stressor in a Population of Drinking Adults.
Shannon M O'Donnell, W Jack Rejeski, Mohammadreza Khodaei, Robert G Lyday, Jonathan H Burdette, Paul J Laurienti, Heather M Shappell
Brain Sciences March 14, 2026 DOI: 10.3390/brainsci16030312 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 32 |
| Population | Moderate-to-heavy drinkers |
| Duration | 10-minute mindfulness session or rest following stress imagery task |
| Topics | Meditation |
| Keywords | Drinking Dynamic brain networks FMRI Hidden semi-markov model Stress |
| Key findings | Mindfulness increased time in salience-network-dominant brain states and transitions between states, while control participants spent more time in default-mode-network-dominant states. |
Abstract
Previous research has found that mindfulness-based techniques are beneficial for reducing stress in heavy-drinking individuals. However, the underlying neurobiology of these stress-reducing effects are unclear. Moreover, much of the research examining neurobiological correlates of mindfulness has used static functional connectivity, suggesting that brain activity goes unchanged for the entire length of an MRI scan. In the current study, we used a state-based dynamic functional connectivity model to examine brain states during either a 10 min mindfulness session or resting control that followed an individually tailored stress imagery task. Using a hidden semi-Markov model (HSMM), six brain states and the associated dynamics of state traversal were estimated for a population of moderate-to-heavy drinkers (N = 32). We modeled the 36 Schaefer atlas regions spanning the salience and default mode networks, and the HSMM characterized each state by its distinct multivariate pattern of activity and covariance structure. Group differences in dwell times, transition behavior, and overall state dynamics were evaluated using permutation tests and mixed-effects models. Participants that experienced the mindfulness session had more transitions and longer time spent in states in which the salience network was more active. Participants assigned to the control group had more transitions and increased time spent in states in which nodes of the default mode network were more active. Moreover, for control participants, increased occupancy time to SN-dominant states was associated with lower perceived stress. Using HSMM provided a unique insight into network connectivity during mindful states; we believe it offers a novel approach to testing and optimizing mindful-based therapies.
Comparable studies
Other randomized controlled trials on meditation, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Alterations in Brain and Immune Function Produced by Mindfulness Meditation Healthy employees in a work environment | 2003 | Randomized controlled trial | n = 41 |
| Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. Recovered recurrently depressed patients | 2000 | Randomized controlled trial | n = 145 |
| Open hearts build lives: Positive emotions, induced through loving-kindness meditation, build consequential personal resources. Working adults | 2008 | Randomized controlled trial | n = 139 |
| Short-term meditation training improves attention and self-regulation Undergraduate Chinese students | 2007 | Randomized controlled trial | n = 40 |
| Mindfulness-Based Cognitive Therapy for Depression: Replication and Exploration of Differential Relapse Prevention Effects. Recovered recurrently depressed patients | 2004 | Randomized controlled trial | n = 73 |
Citations in the library
Cites 19
- Meditation experience is associated with differences in default mode network activity and connectivity Proceedings of the National Academy of Sciences November 23, 2011
- 20 years of the default mode network: A review and synthesis Neuron May 10, 2023
- Effects of Meditation Experience on Functional Connectivity of Distributed Brain Networks Frontiers in Human Neuroscience 2012
- Mindfulness Meditation for Alcohol Relapse Prevention: A Feasibility Pilot Study Journal of Addiction Medicine May 4, 2008
- Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks Frontiers in Human Neuroscience August 25, 2015
and 14 more in the library