Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations
Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M. Ford, Guillermo Horga, Daniel S. Margulies, Simon McCarthy-Jones, Georg Northoff, James M Shine, Jessica A. Turner, Vincent G Van de Ven, Remko Van Lutterveld, Flavie Waters, Renaud Jardri
Schizophrenia Bulletin June 8, 2016 DOI: 10.1093/schbul/sbw078 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Default mode network |
| Keywords | Resting State FMRI Auditory hallucination Salience neuroscience Psychopathology Cognitive psychology Population Cognition Psychosis Clinical psychology |
| Citations | 134 |
| Key findings | Auditory hallucinations are associated with resting connectivity differences in left-hemisphere auditory and language regions and atypical default mode network interactions with cognitive control and salience networks, with some changes also seen in visual hallucinations. |
Abstract
In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.
Comparable studies
Other narrative reviews on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The Brain's Default Mode Network | 2015 | Review | |
| Default Mode Network Activity and Connectivity in Psychopathology | 2012 | Review | |
| 20 years of the default mode network: A review and synthesis | 2023 | Review | |
| On the relationship between the “default mode network” and the “social brain” | 2012 | Review | |
| The default mode network and social understanding of others: what do brain connectivity studies tell us Healthy subjects, with some studies on patients with autism and psychopathy | 2014 | Review |
Citations in the library
Cited by 12
- Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison Schizophrenia Bulletin August 5, 2020
- Common and distinct brain networks of autoscopic phenomena. NeuroImage: Clinical 2021
- Dopamine-Induced Dysconnectivity Between Salience Network and Auditory Cortex in Subjects With Psychotic-like Experiences: A Randomized Double-Blind Placebo-Controlled Study Schizophrenia Bulletin October 8, 2019
- A working model of neural activity and phenomenal experience in psychosis. Molecular Psychiatry December 1, 2024
- The future of hallucination research: Can hallucinogens and psychedelic drugs teach us anything? Psychiatry Research 2023
and 7 more in the library
Cites 11
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Default Mode Network Activity and Connectivity in Psychopathology Annual Review of Clinical Psychology March 29, 2012
- An Interoceptive Predictive Coding Model of Conscious Presence Frontiers in Psychology 2012
- The salience network is responsible for switching between the default mode network and the central executive network: Replication from DCM Neuroimage May 24, 2014
- From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis. Schizophrenia Research November 1, 2005
and 6 more in the library