Hallucinogen-persisting perception disorder
Leo Hermle, Melanie Simon, Martin Ruchsow, Martin Geppert
Therapeutic Advances in Psychopharmacology October 1, 2012 DOI: 10.1177/2045125312451270 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 33-year-old female patient with HPPD after LSD abuse |
| Intervention | Lamotrigine |
| Key findings | Lamotrigine almost completely resolved complex visual disturbances in a patient with HPPD after other treatments failed. |
Abstract
A 33-year-old female patient developed a hallucinogen-persisting perception disorder (HPPD) after lysergic acid diethylamide (LSD) abuse for a year at the age of 18. Specifically, she reported after images, perception of movement in her peripheral visual fields, blurring of small patterns, halo effects, and macro- and micropsia. Previous treatment with antidepressants and risperidone failed to ameliorate these symptoms. Upon commencing drug therapy with lamotrigine, these complex visual disturbances receded almost completely. Based on its hypothesized neuroprotective and mood-stabilizing effects, the antiepileptic lamotrigine may offer a promising new approach in the treatment of HPPD.
Citations in the library
Cited by 34
- Long-term effects of psychedelic drugs: A systematic review Neuroscience & Biobehavioral Reviews March 16, 2020
- Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives Brain Sciences March 16, 2018
- Psilocybin as a New Approach to Treat Depression and Anxiety in the Context of Life-Threatening Diseases—A Systematic Review and Meta-Analysis of Clinical Trials Biomedicines September 5, 2020
- The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review Frontiers in Psychiatry November 20, 2017
- Psychedelic integration challenges: Participant experiences after a psilocybin truffle retreat in the Netherlands Journal of Psychedelic Studies January 16, 2023
and 29 more in the library
Cites 16
- Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Biological Psychiatry December 1, 1992
- Visual Phenomenology of the LSD Flashback Archives of General Psychiatry August 1, 1983
- The psychopharmacology of hallucinogens. Neuropsychopharmacology April 1, 1996
- Adverse consequences of lysergic acid diethylamide Addiction October 1, 1993
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
and 11 more in the library