Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans.
S Yajnik, P Thapar, J L Lichtor, T Patterson, James P Zacny
Drug and Alcohol Dependence December 1, 1994 DOI: 10.1016/0376-8716(94)90149-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experiment Peer reviewed |
|---|---|
| Population | Marijuana users and non-users |
| Intervention | Nitrous oxide |
| Dose | 40% nitrous oxide in oxygen |
| Topics | Cannabis |
| Key findings | Marijuana users and non-users did not differ in their choice to inhale nitrous oxide, but marijuana users reported intensified subjective effects from nitrous oxide. |
Abstract
An experiment using marijuana users and non-users was conducted to assess whether the reinforcing, subjective, or psychomotor effects of nitrous oxide were influenced by a subject's drug history. Subjects in the first four sessions sampled 40% nitrous oxide in oxygen and 100% oxygen (placebo), and then over the next three sessions, chose which agent they wished to inhale. Choice distributions between the two groups did not differ significantly, and nitrous oxide choice rates were less than 50% in both groups. However, a history of marijuana use appeared to intensify some of the subjective effects induced by nitrous oxide inhalation.
Comparable studies
Other experimental studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Smoked Cannabis' Psychomotor and Neurocognitive Effects in Occasional and Frequent Smokers Occasional (<2x/week) and frequent (≥4x/week) cannabis smokers | 2015 | Controlled within-subjects study | n = 25 |
| Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity Healthy volunteers experienced with cannabis but not regular users | 2019 | Within-subjects experimental design | n = 17 |
| Which biological and self-report measures of cannabis use predict cannabis dependency and acute psychotic-like effects? Young cannabis users | 2018 | Observational study (naturalistic, within-subject counterbalanced design) | n = 410 |
| Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects Healthy volunteers | 2018 | Experimental study | n = 5 |
| Coming off cannabis: a cognitive and magnetic resonance imaging study in patients with multiple sclerosis Patients with multiple sclerosis who began using cannabis after disease onset, used it... | 2019 | Quasi-experimental study with odd-even allocation | n = 40 |
Citations in the library
Cited by 4
- Rewarding Subjective Effects of the NMDAR Antagonist Nitrous Oxide (Laughing Gas) Are Moderated by Impulsivity and Depressive Symptoms in Healthy Volunteers. The International Journal of Neuropsychopharmacology July 23, 2021
- Effects of information on the reinforcing, subjective, and psychomotor effects of nitrous oxide in healthy volunteers. Drug and Alcohol Dependence November 25, 1997
- The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug and Alcohol Dependence April 14, 1997
- Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacology, Biochemistry, and Behavior June 1, 1996
Cites 11
- Effects of naloxone on the subjective and psychomotor effects of nitrous oxide in humans. Pharmacology, Biochemistry, and Behavior November 1, 1994
- The subjective, behavioral and cognitive effects of subanesthetic concentrations of isoflurane and nitrous oxide in healthy volunteers. Psychopharmacology April 1, 1994
- Reinforcing effects of extended inhalation of a low nitrous oxide concentration in humans. Pharmacology, Biochemistry, and Behavior December 1, 1993
- Subjective and psychomotor effects of bolus doses of nitrous oxide in humans Human Psychopharmacology: Clinical and Experimental March 1, 1993
- Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug and Alcohol Dependence February 1, 1993
and 6 more in the library