The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers.
A M Cho, Dennis W. Coalson, P A Klock, Jerome M Klafta, S Marks, A Y Toledano, J L Apfelbaum, James P Zacny
Drug and Alcohol Dependence April 14, 1997 DOI: 10.1016/s0376-8716(97)01346-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental Peer reviewed |
|---|---|
| Sample size | 19 |
| Population | Healthy volunteers with different alcohol histories |
| Intervention | Nitrous oxide |
| Dose | 10-40% concentration |
| Duration | Four-session experiment |
| Key findings | Moderate drinkers chose nitrous oxide significantly more often than light drinkers, indicating alcohol history may modulate the reinforcing effects of nitrous oxide. |
Abstract
The purpose of this study was to characterize the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers with different alcohol histories. Subjects were divided into two groups: light drinkers (n = 9) and moderate drinkers (n = 10). A choice procedure was used in which subjects first sampled placebo and a given concentration of nitrous oxide, and then chose between the two. Nitrous oxide concentration varied across the four-session experiment from 10-40%. Besides choice, subjective and psychomotor effects served as dependent measures. The majority of subjective effects of nitrous oxide, and its psychomotor-impairing effects, did not vary as a function of drinking group. However, a Wilcoxon rank sum test showed that the median number of times moderate drinkers chose nitrous oxide (three) was significantly higher than the median number of times light drinkers chose nitrous oxide (one). This study provides suggestive evidence that the reinforcing effects of nitrous oxide are modulated by alcohol history.
Citations in the library
Cited by 6
- Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteers. Drug and Alcohol Dependence December 1, 2010
- Choice of nitrous oxide and its subjective effects in light and moderate drinkers. Drug and Alcohol Dependence November 1, 2008
- Analysis of the reinforcing and subjective effects of different doses of nitrous oxide using a free-choice procedure. Drug and Alcohol Dependence March 1, 2002
- Preoperative dental anxiety and mood changes during nitrous oxide inhalation. Journal of the American Dental Association (1939) January 2002
- Within- and between-subject variability in the reinforcing and subjective effects of nitrous oxide in healthy volunteers. Drug and Alcohol Dependence September 1, 2001
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Cites 6
- Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans. Drug and Alcohol Dependence December 1, 1994
- Reinforcing effects of extended inhalation of a low nitrous oxide concentration in humans. Pharmacology, Biochemistry, and Behavior December 1, 1993
- Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug and Alcohol Dependence February 1, 1993
- Effects of a subanaesthetic concentration of nitrous oxide on memory and subjective experience: Influence of assessment procedures and types of stimuli Human Psychopharmacology: Clinical and Experimental December 1, 1988
- EFFECTS OF NITROUS OXIDE ON SUBJECTIVE AND OBJECTIVE VARIABLES Scandinavian Journal of Psychology March 1, 1963
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