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Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.

S Yajnik, James P Zacny, C J Young, J L Lichtor, G Rupani, Jerome M Klafta, Dennis W. Coalson, J L Apfelbaum

Pharmacology, Biochemistry, and Behavior June 1, 1996 DOI: 10.1016/0091-3057(95)02278-3 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Crossover, double-blind trial Peer reviewed
Sample size 11
Population Healthy volunteers
Intervention Nitrous oxide
Dose 0, 10, 20, 30, and 40%
Duration 120-min inhalation
Key findings Little evidence of acute drug tolerance to the subjective, cognitive, or psychomotor effects of nitrous oxide at any concentration tested over 120 minutes.

Abstract

A crossover, double-blind trial was conducted using eleven healthy volunteers to determine whether and the degree to which acute drug tolerance occurred to the subjective, cognitive, and psychomotor effects of a range of subanesthetic nitrous oxide doses (0, 10, 20, 30, and 40%). There was little evidence of acute drug tolerance to the subjective measures or to the cognitive/psychomotor impairing effects of nitrous oxide at any of the concentrations tested over the course of the 120-min inhalation.

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