Resting state functional connectivity in the default mode network: Relationships between cannabis use, gender, and cognition in adolescents and young adults
Megan M. Ritchay, A. Huggins, Alexander L. Wallace, C. Larson, Krista M. Lisdahl
NeuroImage: Clinical April 8, 2021 DOI: 10.1016/j.nicl.2021.102664 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Cannabis users and healthy controls |
| Duration | ≥ 3 weeks of cannabis abstinence |
| Topics | Cannabis Default mode network |
| Key findings | Cannabis users displayed abnormal resting-state connectivity in the DMN compared to controls, which was related to poorer cognitive performance and may persist after at least three weeks of abstinence. |
Abstract
Highlights • We examined resting state connectivity in the DMN in cannabis users and controls.• Cannabis users displayed abnormal connectivity compared to healthy controls.• Abnormal connectivity in cannabis users related to poorer cognitive performance.• Abnormal brain communication may remain after ≥ 3 weeks of cannabis abstinence.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 13
- Multimodal MRI data fusion reveals distinct structural, functional and neurochemical correlates of heavy cannabis use Addiction Biology November 22, 2021
- Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study Frontiers in Aging Neuroscience February 1, 2023
- Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults Journal of Psychopharmacology July 29, 2023
- Altered reward-related resting-state network properties in adolescent cannabis use and depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry July 13, 2026
- How adolescent cannabis use reshapes the developing brain — a systematic review Frontiers in Psychiatry April 27, 2026
and 8 more in the library
Cites 27
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Default Mode Network Activity and Connectivity in Psychopathology Annual Review of Clinical Psychology March 29, 2012
- Age-related alterations in default mode network: Impact on working memory performance Neurobiology of Aging August 1, 2008
- Default mode network connectivity: effects of age, sex, and analytic approach Neuroreport May 28, 2008
- Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network Neuroimage September 18, 2012
and 22 more in the library