Trace Indoleamines in the Central Nervous System
D. L. Murphy, L. Tamarkin, N. A. Garrick, P. L. Taylor, S. P. Markey
Humana Press eBooks 1985 DOI: 10.1007/978-1-4612-5010-4_36 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Serotonin |
| Keywords | Tryptamines Biogenic amine Trace psycholinguistics Hallucinogen Amine gas treating Tertiary amine |
| Citations | 3 |
| Key findings | Tryptamine is a recognized trace amine in the brain, and other indoleamines, including melatonin and hallucinogenic tryptamines, may also have direct brain actions. |
Abstract
Tryptamine has been widely accepted as a trace amine in brain, and several reviews of its metabolism, regional localization in brain, and possible neuroregulatory functions have been published (Jones, 1982; Juorio and Durden, 1984). Other endogenously synthesized indoleamines have received only minimal attention in several review monographs and symposium volumes devoted to the trace amines (Baldessarini and Fischer, 1978; Mosnaim and Wolf, 1978, 1980; Boulton et al., 1984). Among these indoleamines are melatonin, N-acetyl serotonin, 5-methoxytryptamine and 6-methoxytryptoline. While these latter substances have been regarded as principally pineal hormones with peripheral actions, recent evidence has suggested that they may also act directly in the brain. Other indoleamines which also have been infrequently discussed in the trace amine literature include the hallucinogenic tryptamines such as N, N dimethyltryptamine(DMT), 5-methoxy DMT and N-methyl DMT.